5-Hydroxynicotinic acid

Base Information Edit

Chemical Name:5-Hydroxynicotinic acid
CAS No.:27828-71-3
Molecular Formula:C6H5NO3
Molecular Weight:139.111
Hs Code.:29333990
European Community (EC) Number:622-583-6
NSC Number:606891
DSSTox Substance ID:DTXSID50182143
Nikkaji Number:J28.110G
Wikidata:Q27455772
ChEMBL ID:CHEMBL2146902
Mol file:27828-71-3.mol

Synonyms:3-Pyridinecarboxylic acid, 5-hydroxy- (9CI);5-hydroxypyridine-3-carboxylate;5-Hydroxy-3-pyridinecarboxylic acid;5-22-05-00113 (Beilstein Handbook Reference);5-hydroxypyridine-3-carboxylic acid;Methyl 6-methylnicotinate;

Suppliers and Price of 5-Hydroxynicotinic acid

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5-Hydroxynicotinic acid
25g
$ 360.00

TRC
5-Hydroxynicotinic acid
250mg
$ 140.00

TCI Chemical
5-Hydroxynicotinic Acid >98.0%(HPLC)(T)
5g
$ 87.00

SynQuest Laboratories
5-Hydroxynicotinic acid 97%
1 g
$ 28.00

SynQuest Laboratories
5-Hydroxynicotinic acid 97%
5 g
$ 42.00

SynQuest Laboratories
5-Hydroxynicotinic acid 97%
25 g
$ 125.00

Sigma-Aldrich
5-Hydroxynicotinic acid 97%
5g
$ 452.00

Sigma-Aldrich
5-Hydroxynicotinic acid 97%
1g
$ 114.00

Matrix Scientific
5-Hydroxynicotinic acid 97%
25g
$ 45.00

Matrix Scientific
5-Hydroxynicotinic acid 97%
100g
$ 115.00

Total 152 raw suppliers

Chemical Property of 5-Hydroxynicotinic acid Edit

Chemical Property:

Vapor Pressure:1.3E-11mmHg at 25°C
Melting Point:299 °C
Boiling Point:519.3 °C at 760 mmHg
PKA:2.08±0.10(Predicted)
Flash Point:267.9 °C
PSA：70.42000
Density:1.485 g/cm³
LogP:0.48540
Storage Temp.:Keep Cold
XLogP3:0
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:139.026943022
Heavy Atom Count:10
Complexity:137

Purity/Quality:

98% min ^*data from raw suppliers

5-Hydroxynicotinic acid ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:C1=C(C=NC=C1O)C(=O)O
Uses 5-Hydroxynicotinic acid is a nicotinic acid analog with potential inhibitory effect on the metabolism nicotinic acid by human platelets. Used in the investigation of the hydroxylation mechanism of the flaovoprotein 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase (MHPCO).

Technology Process of 5-Hydroxynicotinic acid

There total 4 articles about 5-Hydroxynicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 20826-04-4
5-bromo-3-pyridinecarboxylic acid

: 27828-71-3
5-hydroxynicotinic acid

Guidance literature:: 5-bromo-3-pyridinecarboxylic acid; With sodium hydroxide; copper; copper(II) sulfate; In water; for 30h; Heating / reflux;

With sodium sulfide; In water; at 20 ℃;

With hydrogenchloride; hydrogen sulfide; more than 3 stages;

Reference yield:

: 24242-19-1
5-aminonicotinic acid

: 27828-71-3
5-hydroxynicotinic acid

Guidance literature:: With sulfuric acid; Diazotization;

Reference yield:

: 36052-25-2
5-amino-nicotinic acid methyl ester

: 27828-71-3
5-hydroxynicotinic acid

Guidance literature:: Multi-step reaction with 2 steps

1: aqueous alkaline solution

2: aqueous H₂SO₄ / Diazotization

With alkaline solution; sulfuric acid;