rac-(R*)-2-Isobutylglycine ethyl ester

Base Information

• Chemical Name: rac-(R*)-2-Isobutylglycine ethyl ester
• CAS No.: 2899-43-6
• Molecular Formula: C8H17NO2
• Molecular Weight: 159.228
• Hs Code.: 2922498590
• Mol file: 2899-43-6.mol

Synonyms:Ethyl 2-amino-4-methylpentanoate;leucine ethyl ester;ethyl leucinate;DL-leucine ethyl ester;DL-Leucin-aethylester;ethyl ester of leucine;

Chemical Property of rac-(R*)-2-Isobutylglycine ethyl ester

Chemical Property:

• Boiling Point: 97-98 °C(Press: 18 Torr)
• PKA: 8.11±0.42(Predicted)
• PSA: 127.76000
• Density: 0.944±0.06 g/cm3(Predicted)
• LogP: 2.35560
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl2-Amino-4-methylpentanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Ethyl 2-Amino-4-Methylpentanoate (cas# 2899-43-6) is used in catalysts for improved stereospecificity in polymerization of propylene.

Technology Process of rac-(R*)-2-Isobutylglycine ethyl ester

There total 11 articles about rac-(R*)-2-Isobutylglycine ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ L-leucine (61-90-5,21675-61-6,25248-98-0,70-45-1) + DL-leucine ethyl ester (2899-43-6,75023-21-1)

Guidance literature:

With pancreasferment;

Reference yield:

2-(Benzhydrylidene-amino)-4-methyl-pentanoic acid ethyl ester (221035-63-8) → DL-leucine ethyl ester (2899-43-6,75023-21-1)

Guidance literature:

With hydrogenchloride; In diethyl ether; at 20 ℃;

DOI:10.1021/jm060325b

Reference yield:

ethanol (64-17-5) + LEUCINE (328-39-2,21675-61-6,25248-98-0,70-45-1) → DL-leucine ethyl ester (2899-43-6,75023-21-1)

Guidance literature:

With hydrogenchloride;

upstream raw materials:

ethanol

LEUCINE

4-methyl-2-(N-nitroso-hydrazino)-valeric acid ethyl ester

DL-leucine methyl ester

Downstream raw materials:

N,N'-carbonyl-di-leucine diethyl ester

N-(N-benzoyl-glycyl)-leucine ethyl ester

2-amino-4-methylpentan-1-ol

2-Amino-4-methyl-pentanoic acid amide

Refernces

• 1、 Venkatraman, Srikanth,Bogen, Stéphane L.,Arasappan, Ashok,Bennett, Frank,Chen, Kevin,Jao, Edwin,Liu, Yi-Tsung,Lovey, Raymond,Hendrata, Siska,Huang, Yuhua,Pan, Weidong,Parekh, Tejal,Pinto, Patrick,Popov, Veljko,Pike, Russel,Ruan, Sumei,Santhanam, Bama,Vibulbhan, Bancha,Wu, Wanli,Yang, Weiying,Kong, Jianshe,Liang, Xiang,Wong, Jesse,Liu, Rong,Butkiewicz, Nancy,Chase, Robert,Hart, Andrea,Agrawal, Sony,Ingravallo, Paul,Pichardo, John,Kong, Rong,Baroudy, Bahige,Malcolm, Bruce,Guo, Zhuyan,Prongay, Andrew,Madison, Vincent,Broske, Lisa,Cui, Xiaoming,Cheng, Kuo-Chi,Hsieh, Yunsheng,Brisson, Jean-Marc,Prelusky, Danial,Korfmacher, Walter,White, Ronald,Bogdanowich-Knipp, Susan,Pavlovsky, Anastasia,Bradley, Prudence,Saksena, Anil K.,Ganguly, Ashit,Piwinski, John,Girijavallabhan, Viyyoor,Njoroge, F. George. "Discovery of (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]-6, 6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (SCH 503034), a selective, potent, orally bioavailable hepatitis C virus NS3 protease inhibitor: A potential therapeutic agent for the treatment of hepatitis C infection". . p. 6074 - 6086. Retrieved 2007/10/03.
• 2、 Tanaka,Matsuo,Nakanishi,Kataoka,Takase,Otsuki. "Syntheses of cyclic hydroxamic acid derivatives, and their chelating abilities and biological activities". . p. 2323 - 2330. Retrieved 2007/10/02.