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221035-63-8

2-(Benzhydrylidene-amino)-4-methyl-pentanoic acid ethyl ester is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 221035-63-8 Structure

  • Basic information

    1. Product Name: 2-(Benzhydrylidene-amino)-4-methyl-pentanoic acid ethyl ester
    2. Synonyms: 2-(Benzhydrylidene-amino)-4-methyl-pentanoic acid ethyl ester
    3. CAS NO:221035-63-8
    4. Molecular Formula:
    5. Molecular Weight: 323.435
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 221035-63-8.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 2-(Benzhydrylidene-amino)-4-methyl-pentanoic acid ethyl ester(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-(Benzhydrylidene-amino)-4-methyl-pentanoic acid ethyl ester(221035-63-8)
    11. EPA Substance Registry System: 2-(Benzhydrylidene-amino)-4-methyl-pentanoic acid ethyl ester(221035-63-8)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 221035-63-8(Hazardous Substances Data)

221035-63-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 221035-63-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,1,0,3 and 5 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 221035-63:
(8*2)+(7*2)+(6*1)+(5*0)+(4*3)+(3*5)+(2*6)+(1*3)=78
78 % 10 = 8
So 221035-63-8 is a valid CAS Registry Number.

221035-63-8Relevant articles and documents

Discovery of (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]-6, 6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (SCH 503034), a selective, potent, orally bioavailable hepatitis C virus NS3 protease inhibitor: A potential therapeutic agent for the treatment of hepatitis C infection

Venkatraman, Srikanth,Bogen, Stéphane L.,Arasappan, Ashok,Bennett, Frank,Chen, Kevin,Jao, Edwin,Liu, Yi-Tsung,Lovey, Raymond,Hendrata, Siska,Huang, Yuhua,Pan, Weidong,Parekh, Tejal,Pinto, Patrick,Popov, Veljko,Pike, Russel,Ruan, Sumei,Santhanam, Bama,Vibulbhan, Bancha,Wu, Wanli,Yang, Weiying,Kong, Jianshe,Liang, Xiang,Wong, Jesse,Liu, Rong,Butkiewicz, Nancy,Chase, Robert,Hart, Andrea,Agrawal, Sony,Ingravallo, Paul,Pichardo, John,Kong, Rong,Baroudy, Bahige,Malcolm, Bruce,Guo, Zhuyan,Prongay, Andrew,Madison, Vincent,Broske, Lisa,Cui, Xiaoming,Cheng, Kuo-Chi,Hsieh, Yunsheng,Brisson, Jean-Marc,Prelusky, Danial,Korfmacher, Walter,White, Ronald,Bogdanowich-Knipp, Susan,Pavlovsky, Anastasia,Bradley, Prudence,Saksena, Anil K.,Ganguly, Ashit,Piwinski, John,Girijavallabhan, Viyyoor,Njoroge, F. George

, p. 6074 - 6086 (2007/10/03)

Hepatitis C virus (HCV) infection is the major cause of chronic liver disease, leading to cirrhosis and hepatocellular carcinoma, which affects more than 170 million people worldwide. Currently the only therapeutic regimens are subcutaneous interferon-α or polyethylene glycol (PEG)-interferon-α alone or in combination with oral ribavirin. Although combination therapy is reasonably successful with the majority of genotypes, its efficacy against the predominant genotype (genotype 1) is moderate at best, with only about 40% of the patients showing sustained virological response. Herein, the SAR leading to the discovery of 70 (SCH 503034), a novel, potent, selective, orally bioavailable NS3 protease inhibitor that has been advanced to clinical trials in human beings for the treatment of hepatitis C viral infections is described. X-ray structure of inhibitor 70 complexed with the NS3 protease and biological data are also discussed.

First Michael addition reaction of α-substituted N-diphenylmethyleneglycinate with ethyl propiolate. Synthesis of α-substituted (E)-3,4-dehydroglutamic acids

Rubio, Almudena,Ezquerra, Jesus

, p. 5823 - 5826 (2007/10/02)

(E)-α-substituted 3,4-dehydro glutamic acids 4, were prepared from ethyl N-diphenylmethyleneglycinate 5 by alkylation with a suitable alkyl halide followed by a Michael type addition reaction with ethyl propiolate, giving rise to a mixture of E/Z adducts 7/8. Sequential hydrolysis of the substituted glycine synthons 7/8 afforded the titled compounds 4 as single diastereomers.

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