Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-5-methyl -, 3'-[2-[(4-methoxybenzoyl)(1-methylethyl)amino]ethyl (S)-bis(1-methylethyl)phosphoramidite]

Base Information

Chemical Name:Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-5-methyl -, 3'-[2-[(4-methoxybenzoyl)(1-methylethyl)amino]ethyl (S)-bis(1-methylethyl)phosphoramidite]
CAS No.:291300-30-6
Molecular Formula:C₅₃H₆₉N₄O₁₂P
Molecular Weight:985.124
Hs Code.:

Uridine,
5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-5-methyl
-, 3'-[2-[(4-methoxybenzoyl)(1-methylethyl)amino]ethyl
(S)-bis(1-methylethyl)phosphoramidite]

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Chemical Property of Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-5-methyl -, 3'-[2-[(4-methoxybenzoyl)(1-methylethyl)amino]ethyl (S)-bis(1-methylethyl)phosphoramidite]

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Technology Process of Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-5-methyl -, 3'-[2-[(4-methoxybenzoyl)(1-methylethyl)amino]ethyl (S)-bis(1-methylethyl)phosphoramidite]

There total 4 articles about Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-5-methyl -, 3'-[2-[(4-methoxybenzoyl)(1-methylethyl)amino]ethyl (S)-bis(1-methylethyl)phosphoramidite] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 109-56-8
i-propyl(2-(hydroxy)ethyl)amine

: 291299-94-0,291300-28-2,291300-30-6
5-methyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(2-methoxyethyl)-3'-O-(N,N-diisopropylamino)-[2-[N-isopropyl-N-(4-methoxybenzoyl)amino]ethoxy]phosphinyluridine

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / tetrahydrofuran / 2 h / 20 °C

2: 84.5 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 0.17 h / -78 °C

3: 96.2 percent / 1H-tetrazole / acetonitrile; CH₂Cl₂ / 2 h / 20 °C

With 1H-tetrazole; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/ja0016396

Reference yield:

: 56183-63-2
bis(diisopropylamino)chlorophosphine

: 291299-94-0,291300-28-2,291300-30-6
5-methyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(2-methoxyethyl)-3'-O-(N,N-diisopropylamino)-[2-[N-isopropyl-N-(4-methoxybenzoyl)amino]ethoxy]phosphinyluridine

Guidance literature:: Multi-step reaction with 2 steps

1: 84.5 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 0.17 h / -78 °C

2: 96.2 percent / 1H-tetrazole / acetonitrile; CH₂Cl₂ / 2 h / 20 °C

With 1H-tetrazole; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile;
DOI:10.1021/ja0016396

Reference yield:

: 100-07-2
4-methoxy-benzoyl chloride

: 291299-94-0,291300-28-2,291300-30-6
5-methyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(2-methoxyethyl)-3'-O-(N,N-diisopropylamino)-[2-[N-isopropyl-N-(4-methoxybenzoyl)amino]ethoxy]phosphinyluridine

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / tetrahydrofuran / 2 h / 20 °C

2: 84.5 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 0.17 h / -78 °C

3: 96.2 percent / 1H-tetrazole / acetonitrile; CH₂Cl₂ / 2 h / 20 °C

With 1H-tetrazole; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/ja0016396