5-METHOXYTHIOPHENE-2-CARBOXYLIC ACID

Base Information

• Chemical Name: 5-METHOXYTHIOPHENE-2-CARBOXYLIC ACID
• CAS No.: 29212-22-4
• Molecular Formula: C6H6O3S
• Molecular Weight: 158.17500
• Hs Code.: 2934999090
• Mol file: 29212-22-4.mol

Synonyms:5-(methoxy)thiophene-2-carboxaldehyde;5-Methoxy-thiophen-2-carbonsaeure;5-methoxy-thiophene-2-carboxylic acid;5-methoxy-2-thiophenecarbaldehyde;2-Thiophenecarboxaldehyde,5-methoxy;5-Methoxy-thiophen-carbonsaeure-(2);5-formyl-2-methoxythiophene;2-(5-methoxythiophene)carboxylic acid;5-methoxy-2-formylthiophene;5-methoxy-thiophene-2-carbaldehyde;5-Methoxy-2-carbonsaeure-thiophen;

Chemical Property of 5-METHOXYTHIOPHENE-2-CARBOXYLIC ACID

Chemical Property:

• PSA: 74.77000
• LogP: 1.45490
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

NLT 98% ^*data from raw suppliers

5-methoxythiophene-2-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-METHOXYTHIOPHENE-2-CARBOXYLIC ACID

There total 5 articles about 5-METHOXYTHIOPHENE-2-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

2-methoxythiophene (16839-97-7) + carbon dioxide (124-38-9,18923-20-1) → 5-methoxythiophene-2-carboxylic acid (29212-22-4)

Guidance literature:

With ethylaluminum dichloride; In hexane; toluene; at 100 ℃; for 3h; under 22502.3 Torr; regioselective reaction; Autoclave; Inert atmosphere;

DOI:10.1246/bcsj.20110335

Reference yield:

2-methoxythiophene (16839-97-7) + n-butyllithium (109-72-8,29786-93-4) → 5-methoxythiophene-2-carboxylic acid (29212-22-4)

Guidance literature:

In tetrahydrofuran; diethyl ether; hexane; carbon dioxide;

Reference yield:

2-methoxythiophene (16839-97-7) → 5-methoxythiophene-2-carboxylic acid (29212-22-4)

Guidance literature:

With diethyl ether; phenyllithium; anschliessend Behandeln mit festem Kohlendioxid;

DOI:10.1021/ja01111a027

upstream raw materials:

2-methoxythiophene

5-bromo-2-methoxythiophene

n-butyllithium

carbon dioxide

Downstream raw materials:

5-methoxythiophene-2-carbonyl chloride

Refernces

• 1、 Nemoto, Koji,Onozawa, Satoru,Konno, Megumi,Morohashi, Naoya,Hattori, Tetsutaro. "Direct carboxylation of thiophenes and benzothiophenes with the aid of EtAlCl2". experimental part. p. 369 - 371. Retrieved 2012/05/05.
• 2、 -. "Antidiabetic furancarboxylic and thiphenecarboxylic acids". . . Retrieved 2008/06/13.