2-(4-Fluorophenoxy)ethanol

Base Information

• Chemical Name: 2-(4-Fluorophenoxy)ethanol
• CAS No.: 2924-66-5
• Molecular Formula: C8H9FO2
• Molecular Weight: 156.157
• Hs Code.: 2909499000
• Mol file: 2924-66-5.mol

Synonyms:2-(4'-fluorophenoxy)ethanol;Ethanol,2-(4-fluorophenoxy);2-(p-fluorophenoxy)ethanol;2-(4-fluorophenoxy)ethan-1-ol;

Chemical Property of 2-(4-Fluorophenoxy)ethanol

Chemical Property:

• PSA: 29.46000
• LogP: 1.19680

Purity/Quality:

99% ^*data from raw suppliers

2-(4-Fluorophenoxy)ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-Fluorophenoxy)ethanol

There total 7 articles about 2-(4-Fluorophenoxy)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

[1,3]-dioxolan-2-one (96-49-1) + 4-Fluorophenol (371-41-5) → 2-(4'-fluorophenoxy)ethanol (2924-66-5)

Guidance literature:

With potassium fluoride; at 160 ℃;

DOI:10.1021/jo00392a017

Reference yield: 96.0%

ethylene glycol (107-21-1) + 1-Bromo-4-fluorobenzene (460-00-4) → 2-(4'-fluorophenoxy)ethanol (2924-66-5)

Guidance literature:

With potassium carbonate; copper dichloride; at 130 ℃; for 20h; Inert atmosphere; Schlenk technique;

DOI:10.1039/c4ob00649f

Reference yield: 80.0%

tert-butyl 2-(4-fluorophenoxy)acetate (167694-82-8) → 2-(4'-fluorophenoxy)ethanol (2924-66-5)

Guidance literature:

tert-butyl 2-(4-fluorophenoxy)acetate; With lithium aluminium tetrahydride; In tetrahydrofuran; at -15 - 20 ℃;

With water; sodium sulfate; sodium hydroxide; In tetrahydrofuran; for 1h;

upstream raw materials:

[1,3]-dioxolan-2-one

4-Fluorophenol

2-(4-fluorophenoxy)ethanoic acid

ethyl 2-(4-fuorophenoxy)acetate

Downstream raw materials:

2-(2-(4-fluorophenoxy)ethyl)isoindoline-1,3-dione

4-Fluorophenol

C₁₁H₁₃FO₃

1-(4-(2-(tert-butyl)phenyl)piperazin-1-yl)-3-(2-(4-fluorophenoxy)ethoxy)propan-2-ol