2-hydroxy-5-chloro-4-methylacetophenone isonicotinoylhydrazone

Base Information

• Chemical Name: 2-hydroxy-5-chloro-4-methylacetophenone isonicotinoylhydrazone
• CAS No.: 1355198-80-9
• Molecular Formula: C₁₅H₁₄ClN₃O₂
• Molecular Weight: 303.748
• Mol file: 1355198-80-9.mol

Synonyms:

Chemical Property of 2-hydroxy-5-chloro-4-methylacetophenone isonicotinoylhydrazone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-hydroxy-5-chloro-4-methylacetophenone isonicotinoylhydrazone

There total 3 articles about 2-hydroxy-5-chloro-4-methylacetophenone isonicotinoylhydrazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chloro-3-methylphenyl acetate (54963-43-8) → 2-hydroxy-5-chloro-4-methylacetophenone isonicotinoylhydrazone (1355198-80-9)

Guidance literature:

Multi-step reaction with 2 steps

1: aluminum (III) chloride

2: Reflux

With aluminum (III) chloride;

Reference yield:

isoniazid (54-85-3,7640-37-1) + 5'-chloro-2'-hydroxy-4'-methyl acetophenone (28480-70-8) → 2-hydroxy-5-chloro-4-methylacetophenone isonicotinoylhydrazone (1355198-80-9)

Guidance literature:

Reflux;

Reference yield:

4-Chloro-3-methylphenol (59-50-7) → 2-hydroxy-5-chloro-4-methylacetophenone isonicotinoylhydrazone (1355198-80-9)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium acetate

2: aluminum (III) chloride

3: Reflux

With aluminum (III) chloride; sodium acetate;

upstream raw materials:

isoniazid

5'-chloro-2'-hydroxy-4'-methyl acetophenone

4-Chloro-3-methylphenol

4-chloro-3-methylphenyl acetate

Refernces