rac-(R*)-2-Amino-3-(4-chlorophenyl)propionic acid ethyl ester

Base Information

• Chemical Name: rac-(R*)-2-Amino-3-(4-chlorophenyl)propionic acid ethyl ester
• CAS No.: 29622-19-3
• Molecular Formula: C11H14ClNO2
• Molecular Weight: 227.691
• Mol file: 29622-19-3.mol

Synonyms:ethyl 2-amino-3-(4-chlorophenyl)propanoate;(R,S)-4-chlorophenylalanine ethyl ester;ethyl 4-chlorophenylalaninate;4-chlorophenylalanine ethyl ester;

Chemical Property of rac-(R*)-2-Amino-3-(4-chlorophenyl)propionic acid ethyl ester

Chemical Property:

• Vapor Pressure: 0.000538mmHg at 25°C
• PSA: 52.32000
• LogP: 2.47320

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of rac-(R*)-2-Amino-3-(4-chlorophenyl)propionic acid ethyl ester

There total 8 articles about rac-(R*)-2-Amino-3-(4-chlorophenyl)propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethanol (64-17-5) + DL-Phe(4Cl) (7424-00-2,1991-78-2) → (±)-ethyl 2-amino-3-(4-chlorophenyl)propanoate (29622-19-3,38964-54-4)

Guidance literature:

ethanol; DL-Phe(4Cl); With thionyl chloride; Reflux;

With sodium hydrogencarbonate;

DOI:10.1016/j.tetasy.2010.02.011

Reference yield: 89.0%

(E)-ethyl 3-(4-chlorophenyl)-2-(hydroxyimino)propanoate (1612831-73-8) → (±)-ethyl 2-amino-3-(4-chlorophenyl)propanoate (29622-19-3,38964-54-4)

Guidance literature:

With iron; zinc; In formic acid; at 50 - 65 ℃; for 2h;

DOI:10.1039/c3gc42432d

Reference yield: 85.0%

ethyl 3-(4-chlorophenyl)-2-(hydroxyimino)propionate (1353886-55-1) → (±)-ethyl 2-amino-3-(4-chlorophenyl)propanoate (29622-19-3,38964-54-4)

Guidance literature:

With hydrogenchloride; zinc; In ethanol; water; at 0 ℃; for 3h;

DOI:10.3762/bjoc.14.264

upstream raw materials:

ethanol

DL-Phe(4Cl)

p-chlorobenzenediazonium tetrafluoroborate

ethyl acrylate

Downstream raw materials:

L-4-chlorophenylalanine ethyl ester

p-chlorophenylalanine

para-Chloro-D-phenylalanine

D-4-chlorophenylalanine ethyl ester

Refernces

• 1、 -. "IMIDAZOPYRAZINE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, AND THEIR USES AS LUCIFERINS". Page/Page column 60; 62. . Retrieved 2018/11/22.
• 2、 De Salas, Cristina,Heinrich, Markus R.. "Fixation and recycling of nitrogen monoxide through carbonitrosation reactions". . p. 2982 - 2987. Retrieved 2014/06/10.