4-Hydroxymethyl-4-methylpiperidine

Base Information

• Chemical Name: 4-Hydroxymethyl-4-methylpiperidine
• CAS No.: 297172-16-8
• Molecular Formula: C7H15NO
• Molecular Weight: 129.202
• Hs Code.: 2933399090
• Mol file: 297172-16-8.mol

Synonyms:4-Hydroxymethyl-4-methylpiperidine;

Chemical Property of 4-Hydroxymethyl-4-methylpiperidine

Chemical Property:

• Vapor Pressure: 0.0787mmHg at 25°C
• Boiling Point: 200.8oC at 760 mmHg
• PKA: 14.94±0.10(Predicted)
• Flash Point: 76.7oC
• PSA: 32.26000
• Density: 0.926g/cm3
• LogP: 0.69720
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%min ^*data from raw suppliers

(4-Methylpiperidin-4-yl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Hydroxymethyl-4-methylpiperidine

There total 9 articles about 4-Hydroxymethyl-4-methylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

(1-benzyl-4-methylpiperidin-4-yl)methanol (878167-03-4) → (4-methylpiperidin-4-yl)methanol (297172-16-8)

Guidance literature:

With hydrogen; ammonium formate; palladium 10% on activated carbon; In methanol; for 18h;

Reference yield: 65.0%

ethyl 4-methylpiperidine-4-carboxylate (103039-88-9) → (4-methylpiperidin-4-yl)methanol (297172-16-8)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/ml300372f

Reference yield:

ethyl 4-methyl-4-piperidine dicarboxylate → (4-methylpiperidin-4-yl)methanol (297172-16-8)

Guidance literature:

ethyl 4-methyl-4-piperidine dicarboxylate; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 4h;

With potassium hydroxide; In tetrahydrofuran; water; for 3h;

upstream raw materials:

(1-benzyl-4-methylpiperidin-4-yl)methanol

tert-butyl 1-benzyl-4-methylpiperidine-4-carboxylate

tert-butyl 1-benzylpiperidine-4-carboxylate

1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate

Downstream raw materials:

ethyl 4-formyl-4-methylpiperidine-1-carboxylate

tert-butyl 4-hydroxy-4-(hydroxymethyl)piperidine-1-carboxylate

tert-Butyl 3-(4-((4-(hydroxymethyl)-4-methylpiperidin-1-yl)methyl)-3-methylphenoxy)azetidine-1-carboxylate

Refernces

• 1、 Sumiyoshi, Takaaki,Enomoto, Takeshi,Takai, Kentaro,Takahashi, Yoko,Konishi, Yasuko,Uruno, Yoshiharu,Tojo, Kengo,Suwa, Atsushi,Matsuda, Harumi,Nakako, Tomokazu,Sakai, Mutsuko,Kitamura, Atsushi,Uematsu, Yasuaki,Kiyoshi, Akihiko. "Discovery of novel N-substituted oxindoles as selective M1 and M4 muscarinic acetylcholine receptors partial agonists". . p. 244 - 248. Retrieved 2013/03/29.
• 2、 -. "1, 7 - DIAZACARBAZOLES AND THEIR USE IN THE TREATMENT OF CANCER". Page/Page column 147. . Retrieved 2011/07/07.