4-ethoxy-1H-pyrazolo[3,4-d]pyrimidine

Base Information

• Chemical Name: 4-ethoxy-1H-pyrazolo[3,4-d]pyrimidine
• CAS No.: 32353-19-8
• Molecular Formula: C7H8 N4 O
• Molecular Weight: 164.167
• Mol file: 32353-19-8.mol

Synonyms:NSC4940

Chemical Property of 4-ethoxy-1H-pyrazolo[3,4-d]pyrimidine

Chemical Property:

• Vapor Pressure: 9.87E-05mmHg at 25°C
• Boiling Point: 348.8°Cat760mmHg
• Flash Point: 127.5°C
• Density: 1.345g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-ethoxy-1H-pyrazolo[3,4-d]pyrimidine

There total 2 articles about 4-ethoxy-1H-pyrazolo[3,4-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

sodium ethanolate (141-52-6) + 4-chloro-1H-pyrazolo[3,4-d]pyrimidine (5399-92-8) → 4-ethoxy-1(2)H-pyrazolo[3,4-d]pyrimidine (32353-19-8)

Guidance literature:

With ethanol;

DOI:10.1021/ja01585a023

Reference yield:

Allopurinol (315-30-0) → 4-ethoxy-1(2)H-pyrazolo[3,4-d]pyrimidine (32353-19-8)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-dimethyl-aniline; POCl₃

2: ethanol

With ethanol; N,N-dimethyl-aniline; trichlorophosphate;

DOI:10.1021/ja01585a023

Reference yield:

4-ethoxy-1(2)H-pyrazolo[3,4-d]pyrimidine (32353-19-8) → 4-ethoxy-3-(6-fluoropyridin-2-yl)-1-trityl-1H-pyrazolo[3,4-d]pyrimidine (1321503-83-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: N-iodo-succinimide / 1,2-dichloro-ethane / 2 h / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

2.2: 18 h / 0 - 20 °C

3.1: sodium carbonate / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 3 h / 60 °C / Inert atmosphere

With N-iodo-succinimide; sodium hydride; sodium carbonate; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In 1,4-dioxane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

sodium ethanolate

4-chloro-1H-pyrazolo[3,4-d]pyrimidine

Allopurinol

Downstream raw materials:

4-ethoxy-3-iodo-1-trityl-1H-pyrazolo[3,4-d]pyrimidine

4-ethoxy-3-(6-fluoropyridin-2-yl)-1-trityl-1H-pyrazolo[3,4-d]pyrimidine