Ethyl 2-oxo-3-phenylpiperidine-3-carboxylate

Base Information

• Chemical Name: Ethyl 2-oxo-3-phenylpiperidine-3-carboxylate
• CAS No.: 63378-71-2
• Molecular Formula: C14H17NO3
• Molecular Weight: 247.294
• NSC Number: 202015
• DSSTox Substance ID: DTXSID50308083
• ChEMBL ID: CHEMBL2141890
• Mol file: 63378-71-2.mol

Synonyms:ethyl 2-oxo-3-phenylpiperidine-3-carboxylate;63378-71-2;MLS003107155;Ethyl2-oxo-3-phenylpiperidine-3-carboxylate;NSC202015;3-Phenyl-3-ethoxycarbonyl piperidine 2-one;Oprea1_445120;SCHEMBL8115016;CHEMBL2141890;DTXSID50308083;AR2399;MFCD01570448;NSC-202015;SB43958;AS-45348;SMR001822033;CS-0172364;Ethyl 2-oxo-3-phenyl-3-piperidinecarboxylate #;A914855;Piperidine-3-carboxylic acid, 2-oxo-3-phenyl-, ethyl ester;(r,s)-2-oxo-3-phenyl-piperidine-3-carboxylic acid ethyl ester

Chemical Property of Ethyl 2-oxo-3-phenylpiperidine-3-carboxylate

Chemical Property:

• Vapor Pressure: 1.9E-07mmHg at 25°C
• Melting Point: 142-143 °C(Solv: water (7732-18-5); ethanol (64-17-5))
• Boiling Point: 425.5°C at 760 mmHg
• PKA: 15.11±0.40(Predicted)
• Flash Point: 211.2°C
• Density: 1.146g/cm³
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 247.12084340
• Heavy Atom Count: 18
• Complexity: 323

Purity/Quality:

97% ^*data from raw suppliers

Ethyl2-oxo-3-phenylpiperidine-3-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCOC(=O)C1(CCCNC1=O)C2=CC=CC=C2

Technology Process of Ethyl 2-oxo-3-phenylpiperidine-3-carboxylate

There total 4 articles about Ethyl 2-oxo-3-phenylpiperidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Diethyl 2-(2-cyanoethyl)-2-phenylmalonate (10444-14-1) → Ethyl 2-oxo-3-phenylpiperidine-3-carboxylate (63378-71-2)

Guidance literature:

With acetic acid; platinum; under 2942.03 Torr; Hydrogenation_.Erhitzen des Reaktionsprodukts mit Toluol;

DOI:10.1021/ja01512a056

Reference yield:

acrylonitrile (107-13-1,25014-41-9) + diethyl 2-phenylmalonate (83-13-6) → Ethyl 2-oxo-3-phenylpiperidine-3-carboxylate (63378-71-2)

Guidance literature:

With potassium hydroxide; hydrogen; platinum(IV) oxide; Multistep reaction; 1.) t-BuOH, MeOH;

Reference yield:

2-(3-Amino-propyl)-2-phenyl-malonic acid diethyl ester (738541-91-8) → Ethyl 2-oxo-3-phenylpiperidine-3-carboxylate (63378-71-2)

Guidance literature:

In ethanol; for 24h; Heating;

DOI:10.1039/b103560f

upstream raw materials:

Diethyl 2-(2-cyanoethyl)-2-phenylmalonate

acrylonitrile

diethyl 2-phenylmalonate

2-(3-Amino-propyl)-2-phenyl-malonic acid diethyl ester

Downstream raw materials:

(RS)-3-phenylpiperidin-2-one

ethyl 2-ethoxy-3-phenyl-3,4,5,6-tetrahydropyridine-3-carboxylate

Ethyl 3-phenyl-2-thioxopiperidine-3-carboxylate

3-Phenylpiperidine-2-thione

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 63378-71-2 Ethyl 2-Oxo-3-Phenylpiperidine-3-Carboxylate

Send

Send

Metric Ton KG G Pound L ML

Send

Send