N-(2-Chloro-6-methylphenyl)-2-((2,6-dimethyl-4-pyrimidinyl)amino)-5-thiazolecarboxamide

Base Information

Chemical Name:N-(2-Chloro-6-methylphenyl)-2-((2,6-dimethyl-4-pyrimidinyl)amino)-5-thiazolecarboxamide
CAS No.:302961-18-8
Molecular Formula:C17H16ClN5OS
Molecular Weight:373.866
Hs Code.:
UNII:N9PH4O199D
Wikidata:Q27076526
Pharos Ligand ID:ZLBBMCUUAG6P
ChEMBL ID:CHEMBL364623
Mol file:302961-18-8.mol

Synonyms:N9PH4O199D;UNII-N9PH4O199D;CHEMBL364623;302961-18-8;compound 2 [PMID: 15546730];5-Thiazolecarboxamide, N-(2-chloro-6-methylphenyl)-2-((2,6-dimethyl-4-pyrimidinyl)amino)-;N-(2-Chloro-6-methylphenyl)-2-((2,6-dimethyl-4-pyrimidinyl)amino)-5-thiazolecarboxamide;N-(2-Chloro-6-methylphenyl)-2-((2,6-dimethylpyrimidin-4-yl)amino)-1,3-thiazole-5-carboxamide;N-(2-chloro-6-methylphenyl)-2-[(2,6-dimethylpyrimidin-4-yl)amino]-1,3-thiazole-5-carboxamide;D08RZB;SCHEMBL774220;GTPL8136;BDBM13268;PMID15546730C2;EN300-18531495;Q27076526;Z2216903638;N-(2-chloro-6-methylphenyl)-2-[(2,6-dimethyl-4-pyrimidinyl)-amino]-1,3-thiazole-5-carboxamide

Suppliers and Price of N-(2-Chloro-6-methylphenyl)-2-((2,6-dimethyl-4-pyrimidinyl)amino)-5-thiazolecarboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(2-Chloro-6-methylphenyl)-2-((2,6-dimethyl-4-pyrimidinyl)amino)-5-thiazolecarboxamide

Chemical Property:

XLogP3:4.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:373.0764090
Heavy Atom Count:25
Complexity:470

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=NC(=NC(=C3)C)C

Technology Process of N-(2-Chloro-6-methylphenyl)-2-((2,6-dimethyl-4-pyrimidinyl)amino)-5-thiazolecarboxamide

There total 9 articles about N-(2-Chloro-6-methylphenyl)-2-((2,6-dimethyl-4-pyrimidinyl)amino)-5-thiazolecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 302964-06-3
[5-(2-chloro-6-methylphenylcarbamoyl)thiazol-2-yl]-carbamic acid tert-butyl ester

: 302961-18-8
N-(2-chloro-6-methylphenyl)-2-[(2,6-dimethyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 51 mg / CF₃CO₂H / CH₂Cl₂ / 2 h / 0 °C

2: 51 percent / CuBr₂; t-BuONO / acetonitrile / 20 °C

3: NaH / tetrahydrofuran / Heating

With tert.-butylnitrite; sodium hydride; trifluoroacetic acid; copper(ll) bromide; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jm060727j

Reference yield:

: 302964-24-5
2-amino-N-(2-chloro-6-methylphenyl)-1.3-thiazole-5-carboxamide

: 302961-18-8
N-(2-chloro-6-methylphenyl)-2-[(2,6-dimethyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 51 percent / CuBr₂; t-BuONO / acetonitrile / 20 °C

2: NaH / tetrahydrofuran / Heating

With tert.-butylnitrite; sodium hydride; copper(ll) bromide; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jm060727j