461-98-3

Basic information

• Product Name: 4-AMINO-2,6-DIMETHYLPYRIMIDINE
• Synonyms: 4-AMINO-2,6-DIMETHYLPYRIMIDINE;AKOS BC-0719;AKOS B029847;6-AMINO-2,4-DIMETHYLPYRIMIDINE;2,6-DIMETHYL-4-PYRIMIDINYLAMINE;KYANMETHIN;LABOTEST-BB LT00000110;4-Amino-2,6-dimethylpylpyrimidine
• CAS NO: 461-98-3
• Molecular Formula: C₆H₉N₃
• Molecular Weight: 123.16
• EINECS: 207-320-1
• Product Categories: PYRIMIDINE;Pyridines, Pyrimidines, Purines and Pteredines;Nucleotides and Nucleosides;Bases & Related Reagents;Nucleotides
• Mol File: 461-98-3.mol
• Article Data: 20

Chemical Properties

• Melting Point: 184-186°C
• Boiling Point: 254 °C
• Flash Point: 121.3 °C
• Appearance: Crystalline solid
• Density: 1.1097 (rough estimate)
• Vapor Pressure: 0.0417mmHg at 25°C
• Refractive Index: 1.5589 (estimate)
• Storage Temp.: -20°C Freezer
• Solubility: DMSO
• PKA: 7.24±0.10(Predicted)
• Water Solubility: 6.4g/L(18 oC)
• Merck: 14,5326
• CAS DataBase Reference: 4-AMINO-2,6-DIMETHYLPYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINO-2,6-DIMETHYLPYRIMIDINE(461-98-3)
• EPA Substance Registry System: 4-AMINO-2,6-DIMETHYLPYRIMIDINE(461-98-3)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-20/21/22-22
• Safety Statements: 26-36/37/39-36
• Hazardous Substances Data: 461-98-3(Hazardous Substances Data)

Usage

Chemical Properties

Crystalline Solid

InChI:InChI=1/C6H9N3/c1-4-3-6(7)9-5(2)8-4/h3H,1-2H3,(H2,7,8,9)

Upstream product

• 1118-61-2 3-Aminocrotononitrile 
• 4472-45-1 4-chloro-2,6-dimethylpyrimidine 
• 7664-41-7 ammonia 
• 75-05-8 acetonitrile 
• 108-24-7 acetic anhydride 
• 143-37-3 acetamidine 
• 142-96-1 dibutyl ether 
• 109-75-1 but-3-enenitrile 
• 124-42-5 acetamidine hydrochloride 
• 70807-22-6 3-hydroxycrotononitrile sodium salt 
• 108260-15-7 2-(iodomethyl)-6-methyl-4-pyrimidinylamine 
• 67-56-1 methanol 
• 823-94-9 2,4,6-trimethyl-s-triazine 

Downstream Products

• 33721-00-5 N-(2,6-dimethylpyrimidin-4-yl)acetamide 
• 79513-89-6 N-(4-chloro-phenyl)-N'-(2,6-dimethyl-pyrimidin-4-yl)-urea 
• 100376-08-7 4-chloro-benzoic acid-(2,6-dimethyl-pyrimidin-4-ylamide) 
• 61736-26-3 4-methyl-7-phenyl-pyrrolo[1,2-a]pyrimidin-2-ylamine 
• 667907-86-0 N-benzenesulfonyl-N-(2,6-dimethyl-pyrimidin-4-yl)-benzenesulfonamide 
• 108236-13-1 [4-(2,6-dimethyl-pyrimidin-4-ylsulfamoyl)-phenyl]-carbamic acid ethyl ester 
• 847700-01-0 4-nitro-benzenesulfonic acid-(2,6-dimethyl-pyrimidin-4-ylamide) 
• 667908-37-4 N-(2,6-dimethyl-pyrimidin-4-yl)-4-nitro-N-(4-nitro-benzensulfonyl)-benzenesulfonamide 
• 515-64-0 Sulfasomidin 
• 112860-70-5 4-acetylamino-N-(4-acetylamino-benzenesulfonyl)-N-(2,6-dimethyl-pyrimidin-4-yl)-benzenesulfonamide 
• 265324-40-1 2-{2-[7-chloro-3-(3,5-dimethyl-phenyl)-6-(2,6-dimethyl-pyrimidin-4-ylcarbamoyl)-2-oxo-1,2-dihydro-quinolin-4-yloxy]-ethyl}-piperidine-1-carboxylic acid tert-butyl ester 
• 79513-84-1 1-(2,6-Dimethyl-pyrimidin-4-yl)-3-o-tolyl-urea 
• 79513-88-5 1-(3-Chloro-phenyl)-3-(2,6-dimethyl-pyrimidin-4-yl)-urea 
• 79513-91-0 1-(2,6-Dimethyl-pyrimidin-4-yl)-3-(3-trifluoromethyl-phenyl)-urea 

Relevant articles and documents

-

-

Temperature controlled condensation of nitriles: Efficient and convenient synthesis of β-enaminonitriles, 4-aminopyrimidines and 4-amidinopyrimidines in one system

A series of β-enaminonitriles, 4-aminopyrimidines and 4-amidinopyrimidines were synthesized by condensation of organonitriles in one system. A wide variety of compounds were obtained in good to excellent yields by simply controlling the reaction temperature. The base-induced transformation process is easy for production. The scope and versatility of the method have been successfully demonstrated with 72 examples. The flexible and diversified characteristics of nitriles were introduced based on electronic effect, steric effect, position of substituted groups and intermolecular hydrogen bonding. An updated reaction mechanism is proposed based on the study of the stoichiometric reaction conditions at variable temperature, and on the investigation of products with cis-trans configuration transformation.

Hydrophosphination using [GeCl{N(SiMe3)2}3] as a pre-catalyst

Transformations catalyzed by germanium are scarce, with examples mainly limited to widely catalyzed processes such as polymerisation of lactide and hydroboration of carbonyls. Reported is the first example of hydrophosphination using a germanium pre-catalyst, yielding anti-Markovnikov products when diphenylphosphine is reacted with styrenes or internal alkynes at room temperature. This journal is

Organoselenium and DMAP co-catalysis: Regioselective synthesis of medium-sized halolactones and bromooxepanes from unactivated alkenes

A catalytic system consisting of bis(4-methoxyphenyl)selenide and 4-(dimethylamino)pyridine (DMAP) has been developed for the regioselective synthesis of medium-sized bromo/iodo lactones and bromooxepanes possessing high transannular strain. 77Se NMR, mass spectrometry and theoretical studies reveal that the reaction proceeds via a quaternary selenium intermediate.