5,6-dimethyl-2-oxo-4-phenyl-1H-pyridine-3-carbonitrile

Base Information

Chemical Name:5,6-dimethyl-2-oxo-4-phenyl-1H-pyridine-3-carbonitrile
CAS No.:30456-37-2
Molecular Formula:C14H12N2O
Molecular Weight:224.262
Hs Code.:
DSSTox Substance ID:DTXSID20354653
Wikidata:Q82132924
Mol file:30456-37-2.mol

Synonyms:BAS 00731577;Oprea1_594234;Oprea1_620721;30456-37-2;DTXSID20354653;AKOS000595497;SR-01000356785;SR-01000356785-1;5,6-Dimethyl-2-oxo-4-phenyl-1,2-dihydropyridine-3-carbonitrile

Suppliers and Price of 5,6-dimethyl-2-oxo-4-phenyl-1H-pyridine-3-carbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of 5,6-dimethyl-2-oxo-4-phenyl-1H-pyridine-3-carbonitrile

Chemical Property:

XLogP3:1.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:224.094963011
Heavy Atom Count:17
Complexity:456

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(NC(=O)C(=C1C2=CC=CC=C2)C#N)C

Technology Process of 5,6-dimethyl-2-oxo-4-phenyl-1H-pyridine-3-carbonitrile

There total 3 articles about 5,6-dimethyl-2-oxo-4-phenyl-1H-pyridine-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 709-79-5,148238-27-1,15795-18-3
(E)-2-cyano-3-phenylacrylamide

: 78-93-3
butanone

: 6-ethyl-2-oxo-4-phenyl-1,2-dihydropyridine-3-carbonitrile

: 30456-37-2
3-cyano-4-phenyl-5,6-dimethyl-2(1H)-pyridone

Guidance literature:: With sodium ethanolate; In ethanol; at 20 ℃;
DOI:10.1039/c4ra06619g

Reference yield: 74.0%

: 100-52-7
benzaldehyde

: 78-93-3
butanone

: 105-34-0
methyl 2-cyanoacetate

: 30456-37-2
3-cyano-4-phenyl-5,6-dimethyl-2(1H)-pyridone

Guidance literature:: With ammonium acetate; In neat (no solvent);
DOI:10.1002/jhet.1632

Reference yield:

: 100-52-7
benzaldehyde

: 6-ethyl-2-oxo-4-phenyl-1,2-dihydropyridine-3-carbonitrile

: 30456-37-2
3-cyano-4-phenyl-5,6-dimethyl-2(1H)-pyridone

Guidance literature:: Multi-step reaction with 2 steps

1: 0.01 h / Microwave irradiation

2: sodium ethanolate / ethanol / 20 °C

With sodium ethanolate; In ethanol; 1: |Knoevenagel Condensation;
DOI:10.1039/c4ra06619g