6-Chlorotrimethoprim

Base Information

Chemical Name:6-Chlorotrimethoprim
CAS No.:30563-87-2
Molecular Formula:C14H17ClN4O3
Molecular Weight:324.767
Hs Code.:
ChEMBL ID:CHEMBL150699
DSSTox Substance ID:DTXSID70482612
Metabolomics Workbench ID:66967
Wikidata:Q27225734

Synonyms:6-chlorotrimethoprim;6-chloro-TMP;6-chloro trimethoprim;CHEBI:351351;30563-87-2;6-chloro-5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-diamine;6-chloro-5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine;CHEMBL150699;SCHEMBL11821666;DTXSID70482612;Q27225734

Suppliers and Price of 6-Chlorotrimethoprim

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
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Total 0 raw suppliers

Chemical Property of 6-Chlorotrimethoprim

Chemical Property:

XLogP3:2.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:5
Exact Mass:324.0989181
Heavy Atom Count:22
Complexity:338

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC(=CC(=C1OC)OC)CC2=C(N=C(N=C2Cl)N)N

Technology Process of 6-Chlorotrimethoprim

There total 7 articles about 6-Chlorotrimethoprim which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.5%

: 37389-83-6
2,4-diamino-5-(3',4',5'-trimethoxy-benzyl)-6-hydroxy-pyrimidine

: 30563-87-2
2,4-diamino-5-(3,4,5-trimethoxybenzyl)-6-chloropyrimidine

Guidance literature:

Reference yield:

: 51323-79-6
2-amino-4,6-dichloro-5-(3,4,5-trimethoxybenzyl)pyrimidine

: 30563-87-2
2,4-diamino-5-(3,4,5-trimethoxybenzyl)-6-chloropyrimidine

Guidance literature:: With ammonia; In ethanol; at 117 ℃; for 7h;
DOI:10.1021/jm00179a012

Reference yield:

: 86-81-7
3,4,5-trimethoxy-benzaldehyde

: 30563-87-2
2,4-diamino-5-(3,4,5-trimethoxybenzyl)-6-chloropyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / TEBA / 1 h / 85 °C

2: 90 percent / H₂ / 10 percent Pd/C / ethyl acetate / 2.5 h

3: Na / methanol / 12 h / Heating

4: PCl₅; POCl₃ / 4 h / Heating

With phosphorus pentachloride; N-benzyl-N,N,N-triethylammonium chloride; hydrogen; sodium; trichlorophosphate; palladium on activated charcoal; In methanol; ethyl acetate;