1-Methoxy-4-{3-[(prop-2-en-1-yl)oxy]prop-1-yn-1-yl}benzene

Base Information

Chemical Name:1-Methoxy-4-{3-[(prop-2-en-1-yl)oxy]prop-1-yn-1-yl}benzene
CAS No.:308240-66-6
Molecular Formula:C13H14O2
Molecular Weight:202.253
Hs Code.:
DSSTox Substance ID:DTXSID60573785
Nikkaji Number:J1.444.128J
Wikidata:Q82462607

Synonyms:308240-66-6;SCHEMBL20702293;DTXSID60573785;1-Methoxy-4-{3-[(prop-2-en-1-yl)oxy]prop-1-yn-1-yl}benzene

Suppliers and Price of 1-Methoxy-4-{3-[(prop-2-en-1-yl)oxy]prop-1-yn-1-yl}benzene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Methoxy-4-{3-[(prop-2-en-1-yl)oxy]prop-1-yn-1-yl}benzene

Chemical Property:

XLogP3:2.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:5
Exact Mass:202.099379685
Heavy Atom Count:15
Complexity:238

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C#CCOCC=C

Technology Process of 1-Methoxy-4-{3-[(prop-2-en-1-yl)oxy]prop-1-yn-1-yl}benzene

There total 2 articles about 1-Methoxy-4-{3-[(prop-2-en-1-yl)oxy]prop-1-yn-1-yl}benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 37614-59-8
4-(4-methoxyphenyl)prop-2-yn-1-ol

: 106-95-6
allyl bromide

: 308240-66-6
1-(3-allyloxy-prop-1-ynyl)-4-methoxy-benzene

Guidance literature:: 4-(4-methoxyphenyl)prop-2-yn-1-ol; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃;

allyl bromide; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1002/chem.200401237

Reference yield:

: 696-62-8
para-iodoanisole

: 308240-66-6
1-(3-allyloxy-prop-1-ynyl)-4-methoxy-benzene

Guidance literature:: Multi-step reaction with 2 steps

1.1: 75 percent / Pd(PPh₃)2Cl₂; CuI; piperidine / toluene / 3 h / 30 - 35 °C

2.1: NaH / tetrahydrofuran / 0 - 20 °C

2.2: 95 percent / tetrahydrofuran / 0 - 20 °C

With piperidine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium hydride; In tetrahydrofuran; toluene; 1.1: Sonogashira reaction;
DOI:10.1016/j.tetasy.2006.03.036

Reference yield: 94.0%

: 98-86-2
acetophenone

: 308240-66-6
1-(3-allyloxy-prop-1-ynyl)-4-methoxy-benzene

: (Z)-1-(2-((4-(4-methoxybenzylidene)tetrahydrofuran-3-yl)methyl)phenyl)ethanone

Guidance literature:: With 1,3-bis-(diphenylphosphino)propane; cobalt(II) bromide; zinc(II) iodide; zinc; In dichloromethane; at 40 ℃; for 2h; Sealed tube; Schlenk technique; Inert atmosphere;
DOI:10.1021/ol501904e