3-(Benzyloxy)cyclobutanone

Base Information

• Chemical Name: 3-(Benzyloxy)cyclobutanone
• CAS No.: 30830-27-4
• Molecular Formula: C11H12O2
• Molecular Weight: 176.215
• Hs Code.: 2914509090
• Mol file: 30830-27-4.mol

Synonyms:3-(Benzyloxy)cyclobutanone;AC1Q6ECN;3-(Benzyl-oxy)cyclobutan-1-one;AG-F-02248;TC-069512;FT-0084475;3-Phenylmethoxycyclobutan-1-one;

Chemical Property of 3-(Benzyloxy)cyclobutanone

Chemical Property:

• Vapor Pressure: 0.003mmHg at 25°C
• Refractive Index: 1.5225
• Boiling Point: 284.832 °C at 760 mmHg
• Flash Point: 126.424 °C
• PSA: 26.30000
• Density: 1.119 g/cm³
• LogP: 1.93470
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

98%, ^*data from raw suppliers

3-(Benzyloxy)cyclobutanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-(Benzyloxy)cyclobutanone is used as a reactant for the synthesis of cyclobutyl derivatives of 2''-deoxyadenosine 5''-triphosphate as inhibitors of HIV-1 reverse transcriptase.

Technology Process of 3-(Benzyloxy)cyclobutanone

There total 12 articles about 3-(Benzyloxy)cyclobutanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3-bromocyclobutan-1-one (23761-24-2) + benzyl alcohol (100-51-6,185532-71-2) → 3-benzyloxy cyclobutanone (30830-27-4)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 0 - 45 ℃; for 8h; Inert atmosphere;

Reference yield: 77.0%

1-methylsulfinyl-1-methylthio-3-benzyloxycyclobutane (917887-34-4) → 3-benzyloxy cyclobutanone (30830-27-4)

Guidance literature:

With perchloric acid; In diethyl ether; water; at 10 - 20 ℃; Solvent; Temperature; Time; Large scale;

Reference yield: 72.0%

3-(benzyloxy)-2,2-dichlorocyclobutanone → 3-benzyloxy cyclobutanone (30830-27-4)

Guidance literature:

With zinc; In acetic acid; at 20 ℃; for 6h; Reflux;

DOI:10.1055/s-0037-1610237

upstream raw materials:

Ketene

benzyl vinyl ether

1-methylsulfinyl-1-methylthio-3-benzyloxycyclobutane

(2-bromo-1-bromomethylethoxymethyl)benzene

Downstream raw materials:

8-<3-(benzyloxy)cyclobutylidene>-4,7-dihydro-4,7-methano-2H-indene

7-<3-(benzyloxy)cyclobutylidene>bicyclo<2.2.1>hept-5-ene-2,3-dione

3-(phenylmethoxy)cyclobutan-1-ol

2-(3-(benzyloxy)cyclobutylidene)acetonitrile

Refernces

• 1、 Lu, Xiao-Yu,Liu, Chuang-Chuang,Jiang, Run-Chuang,Yan, Lu-Yu,Liu, Qi-Le,Wang, Qing-Qing,Li, Jia-Mei. "Synthesis of trisubstituted alkenes by Ni-catalyzed hydroalkylation of internal alkynes with cycloketone oxime esters". supporting information. p. 14191 - 14194. Retrieved 2020/11/24.
• 2、 -. "Novel CDK inhibitory compounds, preparation method thereof, pharmaceutical composition for use in preventing or treating CDK relating diseases containing the same as an active ingredient". Paragraph 0261-0263; 0265. . Retrieved 2018/10/24.