3-(Benzyloxy)cyclobutanol

Base Information

• Chemical Name: 3-(Benzyloxy)cyclobutanol
• CAS No.: 100058-61-5
• Molecular Formula: C11H14O2
• Molecular Weight: 178.231
• Hs Code.: 2909499000
• Mol file: 100058-61-5.mol

Synonyms:3-(Benzyloxy)cyclobutanol;3-(benzyloxy)cyclobutan-1-ol

Chemical Property of 3-(Benzyloxy)cyclobutanol

Chemical Property:

• PSA: 29.46000
• LogP: 1.72650
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

3-(Benzyloxy)cyclobutanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(Benzyloxy)cyclobutanol

There total 4 articles about 3-(Benzyloxy)cyclobutanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-benzyloxy cyclobutanone (30830-27-4) → 3-(phenylmethoxy)cyclobutan-1-ol (100058-61-5)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 0 ℃; for 2.5h;

Reference yield:

benzyl bromide (100-39-0) → 3-(phenylmethoxy)cyclobutan-1-ol (100058-61-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: mercury(I) chloride / 150 °C

2.1: n-butyllithium / tetrahydrofuran / 2 h / -10 °C / Inert atmosphere

2.2: -78 - 20 °C

3.1: perchloric acid / diethyl ether / 0 - 20 °C

4.1: sodium tetrahydroborate / ethanol / 2.5 h / 0 °C

With sodium tetrahydroborate; n-butyllithium; perchloric acid; mercury(I) chloride; In tetrahydrofuran; diethyl ether; ethanol;

Reference yield:

1-(methylsulfinyl)-1-methylthio-3-(phenylmethoxy)cyclobutane → 3-(phenylmethoxy)cyclobutan-1-ol (100058-61-5)

Guidance literature:

Multi-step reaction with 2 steps

1: perchloric acid / diethyl ether / 0 - 20 °C

2: sodium tetrahydroborate / ethanol / 2.5 h / 0 °C

With sodium tetrahydroborate; perchloric acid; In diethyl ether; ethanol;

upstream raw materials:

3-benzyloxy cyclobutanone

(2-bromo-1-bromomethylethoxymethyl)benzene

benzyl bromide

Downstream raw materials:

3-(benzyloxy)cyclobutyl methanesulfonate

5-(phenylmethoxy)-2-[3-(phenylmethoxy)cyclobutoxy]pyrimidine

(3-(benzyloxy)cyclobutoxy)benzene

(3-(benzyloxy)cyclobutyl)(2,5-difluorophenyl)sulfane