Benzamide, 2-chloro-N-[(tetrahydro-2H-pyran-2-yl)oxy]-6-[[4-[4-(trifluoromethyl)phen oxy]-1-piperidinyl]sulfonyl]-

Base Information

Chemical Name:Benzamide, 2-chloro-N-[(tetrahydro-2H-pyran-2-yl)oxy]-6-[[4-[4-(trifluoromethyl)phen oxy]-1-piperidinyl]sulfonyl]-
CAS No.:308386-01-8
Molecular Formula:C₂₄H₂₆ClF₃N₂O₆S
Molecular Weight:562.994
Hs Code.:
Mol file:308386-01-8.mol

Synonyms:

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Chemical Property of Benzamide, 2-chloro-N-[(tetrahydro-2H-pyran-2-yl)oxy]-6-[[4-[4-(trifluoromethyl)phen oxy]-1-piperidinyl]sulfonyl]-

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Technology Process of Benzamide, 2-chloro-N-[(tetrahydro-2H-pyran-2-yl)oxy]-6-[[4-[4-(trifluoromethyl)phen oxy]-1-piperidinyl]sulfonyl]-

There total 5 articles about Benzamide, 2-chloro-N-[(tetrahydro-2H-pyran-2-yl)oxy]-6-[[4-[4-(trifluoromethyl)phen oxy]-1-piperidinyl]sulfonyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 28033-37-6
4-[4-(trifluoromethyl)-phenoxy]piperidine

: 308386-01-8
2-chloro-N-(tetrahydro-pyran-2-yloxy)-6-[4-(4-trifluoromethyl-phenoxy)-piperidine-1-sulfonyl]-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: TEA; DMAP / CH₂Cl₂

2: t-BuLi / -40 °C

3: oxalyl chloride / CH₂Cl₂

4: pyridine / CH₂Cl₂

With pyridine; dmap; oxalyl dichloride; TEA; tert.-butyl lithium; In dichloromethane;
DOI:10.1016/S0960-894X(01)00487-5

Reference yield:

: 2888-06-4
3-chlorophenylsulfonyl chloride

: 308386-01-8
2-chloro-N-(tetrahydro-pyran-2-yloxy)-6-[4-(4-trifluoromethyl-phenoxy)-piperidine-1-sulfonyl]-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: TEA; DMAP / CH₂Cl₂

2: t-BuLi / -40 °C

3: oxalyl chloride / CH₂Cl₂

4: pyridine / CH₂Cl₂

With pyridine; dmap; oxalyl dichloride; TEA; tert.-butyl lithium; In dichloromethane;
DOI:10.1016/S0960-894X(01)00487-5

Reference yield:

: 308386-33-6
1-(3-chloro-benzenesulfonyl)-4-(4-trifluoromethyl-phenoxy)-piperidine

: 308386-01-8
2-chloro-N-(tetrahydro-pyran-2-yloxy)-6-[4-(4-trifluoromethyl-phenoxy)-piperidine-1-sulfonyl]-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: t-BuLi / -40 °C

2: oxalyl chloride / CH₂Cl₂

3: pyridine / CH₂Cl₂

With pyridine; oxalyl dichloride; tert.-butyl lithium; In dichloromethane;
DOI:10.1016/S0960-894X(01)00487-5