Phosphine oxide, 1-naphthalenyldiphenyl-

Base Information

• Chemical Name: Phosphine oxide, 1-naphthalenyldiphenyl-
• CAS No.: 3095-33-8
• Molecular Formula: C22H17OP
• Molecular Weight: 328.35
• DSSTox Substance ID: DTXSID30452331
• Nikkaji Number: J305.681C
• Wikidata: Q82272892
• Mol file: 3095-33-8.mol

Synonyms:Phosphine oxide, 1-naphthalenyldiphenyl-;3095-33-8;1-diphenylphosphorylnaphthalene;SCHEMBL9422307;1-naphthyldiphenylphosphine oxide;DTXSID30452331;(naphthalen-1-yl)diphenylphosphine oxide

Chemical Property of Phosphine oxide, 1-naphthalenyldiphenyl-

Chemical Property:

• XLogP3: 5.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 328.101702159
• Heavy Atom Count: 24
• Complexity: 425

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)P(=O)(C2=CC=CC=C2)C3=CC=CC4=CC=CC=C43

Technology Process of Phosphine oxide, 1-naphthalenyldiphenyl-

There total 50 articles about Phosphine oxide, 1-naphthalenyldiphenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

N,N-dimethyl-N-phenylnaphthalen-1-ammonium triflate + Diphenylphosphine oxide (4559-70-0) → N,N'-dimethylbenzylamine (103-83-3) + (naphthalen-1-yl)diphenylphosphine oxide (3095-33-8)

Guidance literature:

With [1,1'-bis(diphenylphosphino)ferrocene]nickel(II) chloride; caesium carbonate; In acetonitrile; at 100 ℃; for 6h; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.joc.8b02926

Reference yield: 91.0%

1-Bromonaphthalene (90-11-9) + Diphenylphosphine oxide (4559-70-0) → (naphthalen-1-yl)diphenylphosphine oxide (3095-33-8)

Guidance literature:

With potassium phosphate; 1,3-bis[(diphenylphosphino)propane]dichloronickel(II); In 1,4-dioxane; at 100 ℃; Inert atmosphere;

DOI:10.1002/chem.201103723

Reference yield: 90.0%

1-Fluoronaphthalene (321-38-0) + Diphenylphosphine oxide (4559-70-0) → (naphthalen-1-yl)diphenylphosphine oxide (3095-33-8)

Guidance literature:

With potassium tert-butylate; In toluene; at 120 ℃; for 20h; Inert atmosphere; Sealed tube;

upstream raw materials:

furan

lithium diphenylphosphide

2,3-dibromobenzene

o-fluorobromobenzene

Downstream raw materials:

1-naphthyl(diphenyl)phosphine

Refernces

• 1、 Stankevi?, Marek,Wo?nicki, Pawe?. "Copper-Catalyzed C?P Cross-Coupling of (Cyclo)alkenyl/Aryl Bromides and Secondary Phosphine Oxides with in situ Halogen Exchange". supporting information. p. 3484 - 3491. Retrieved 2021/07/22.
• 2、 Yan, Wenjie,Zhou, Hongbo,Li, Haoyuan,Hu, Huimin,Yu, Ying,Guo, Shengmei,Cai, Hu. "NiCl 2as a Cheap and Efficient Precatalyst for the Coupling of Aryl Fluorosulfonate and Phosphite/Phosphine Oxide". . p. 1453 - 1456. Retrieved 2021/07/20.