(Z)-3-CHLORO-2-METHYL-3-PHENYL-ACRYLALDEHYDE

Base Information

• Chemical Name: (Z)-3-CHLORO-2-METHYL-3-PHENYL-ACRYLALDEHYDE
• CAS No.: 31357-82-1
• Molecular Formula: C10H9ClO
• Molecular Weight: 180.634
• Hs Code.: 2913000090
• Mol file: 31357-82-1.mol

Synonyms:α-methyl-β-phenyl-β-chloroacrolein;Z-7-chloro-2-(S-2,2-dimethylcyclopropane carboxamido)-2-hetenate sodium;trans-β-Chloro-α-methylcinnamaldehyd;3-Chlor-2-methyl-3-phenyl-2-propenal;(E)-α-Methyl-β-chlorzimtaldehyd;(Z)-3-CHLORO-2-METHYL-3-PHENYL-ACRYLALDEHYDE;

Chemical Property of (Z)-3-CHLORO-2-METHYL-3-PHENYL-ACRYLALDEHYDE

Chemical Property:

• PSA: 17.07000
• LogP: 2.85530

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (Z)-3-CHLORO-2-METHYL-3-PHENYL-ACRYLALDEHYDE

There total 2 articles about (Z)-3-CHLORO-2-METHYL-3-PHENYL-ACRYLALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,N-dimethyl-formamide (68-12-2,33513-42-7) + 1-phenyl-propan-1-one (93-55-0) → (Z)-β-chloro-α-methyl-β-phenylacrolein (31357-81-0) + (E)-β-chloro-α-methyl-β-phenylacrolein (31357-82-1)

Guidance literature:

With trichlorophosphate; at 60 - 70 ℃; for 6h; Yield given. Yields of byproduct given;

DOI:10.1080/00397919508015433

Reference yield:

N,N-dimethyl-formamide (68-12-2,33513-42-7) + 1-phenyl-propan-1-one (93-55-0) → (E)-β-chloro-α-methyl-β-phenylacrolein (31357-82-1)

Guidance literature:

With trichlorophosphate;

DOI:10.1039/j39700002484

Reference yield: 95.0%

2-propylidene malonic acid dimethyl ester (18795-82-9) + (E)-β-chloro-α-methyl-β-phenylacrolein (31357-82-1) → (2E,4E,6E)-7-chloro-2-(methoxycarbonyl)-4,6-dimethyl-7-phenylhepta-2,4,6-trienoic acid

Guidance literature:

With N-benzyl-trimethylammonium hydroxide; In methanol; at 20 ℃; for 48h;

DOI:10.1002/jhet.2419

upstream raw materials:

N,N-dimethyl-formamide

1-phenyl-propan-1-one

Downstream raw materials:

2-Methyl-3-morpholino-3-phenyl-2-propenal

4,4'-<3,3'-Oxybis(2-methyl-1-phenyl-2-propenyliden)>dimorpholinium-bis(trifluormethansulfonat)

4-<2-Methyl-1-phenyl-3-(trifluormethylsulfonyloxy)-2-propenyliden>morpholinium-trifluormethansulfonat

(E)-2-methyl-3-(methylthio)-3-phenylacrylaldehyde

Refernces

• 1、 Komkov, Alexander V.,Komendantova, Anna S.,Menchikov, Leonid G.,Chernoburova, Elena I.,Volkova, Yulia A.,Zavarzin, Igor V.. "A Straightforward Approach toward Multifunctionalized Pyridazines via Imination/Electrocyclization". supporting information. p. 3734 - 3737. Retrieved 2015/08/18.
• 2、 Shaffer, Andrew R.,Schmidt, Joseph A. R.. "A versatile methodology for the synthesis of α,β-unsaturated 3-iminophosphines". experimental part. p. 2662 - 2673. Retrieved 2009/12/03.