1-(Trimethylsilyl)cyclopropanecarboxylic acid

Base Information

• Chemical Name: 1-(Trimethylsilyl)cyclopropanecarboxylic acid
• CAS No.: 31469-29-1
• Molecular Formula: C₇H₁₄O₂Si
• Molecular Weight: 158.272
• European Community (EC) Number: 889-839-9
• Mol file: 31469-29-1.mol

Synonyms:31469-29-1;1-(TRIMETHYLSILYL)CYCLOPROPANECARBOXYLIC ACID;1-(trimethylsilyl)cyclopropane-1-carboxylic acid;Cyclopropanecarboxylic acid, 1-(trimethylsilyl)-;MFCD09868747;1-trimethylsilylcyclopropane-1-carboxylic acid;1-(TRIMETHYLSILYL)CYCLOPROPANECARBOXYLICACID;SCHEMBL9314410;AC1254;AKOS028113824;PB42521;1-trimethylsilylcyclopropanecarboxylic acid;CS-12216;SY040292;CS-0052784;EN300-7418699

Chemical Property of 1-(Trimethylsilyl)cyclopropanecarboxylic acid

Chemical Property:

• PSA: 37.30000
• LogP: 1.94340
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 158.076306220
• Heavy Atom Count: 10
• Complexity: 165

Purity/Quality:

97% ^*data from raw suppliers

1-(Trimethylsilyl)cyclopropanecarboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C[Si](C)(C)C1(CC1)C(=O)O

Technology Process of 1-(Trimethylsilyl)cyclopropanecarboxylic acid

There total 3 articles about 1-(Trimethylsilyl)cyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cyclopropanecarboxylic acid (1759-53-1) → (1'-(trimethylsilyl)cyclopropyl)carboxylic acid (31469-29-1)

Guidance literature:

With n-butyllithium; chloro-trimethyl-silane; diisopropylamine; In tetrahydrofuran; methanol; hexane;

Reference yield:

Trimethylsilyl-α-trimethylsilyl-cyclopropan-carboxilat (31580-84-4) → (1'-(trimethylsilyl)cyclopropyl)carboxylic acid (31469-29-1)

Guidance literature:

With methanol;

DOI:10.1016/S0022-328X(00)90476-5

Reference yield:

chloro-trimethyl-silane (75-77-4) + cyclopropanecarboxylic acid (1759-53-1) → (1'-(trimethylsilyl)cyclopropyl)carboxylic acid (31469-29-1)

Guidance literature:

With lithium diisopropyl amide; Yield given. Multistep reaction; 1.) THF, 0 deg C, 10 min, 2.) room temperature, 3 h;

DOI:10.1021/jo00344a030

upstream raw materials:

Trimethylsilyl-α-trimethylsilyl-cyclopropan-carboxilat

chloro-trimethyl-silane

cyclopropanecarboxylic acid

Downstream raw materials:

N-(2-bromophenyl)-1,1,1-trifluoro-N-((1-(trimethylsilyl)cyclopropyl)methyl)methanesulfonamide

C₁₃H₂₀BrNSi

C₁₃H₁₈BrNOSi

2-(1-trimethylsilylcyclopropyl)cyclohexanone