1-(4-METHOXYBENZYL)-1H-INDOLE-2,3-DIONE

Base Information

• Chemical Name: 1-(4-METHOXYBENZYL)-1H-INDOLE-2,3-DIONE
• CAS No.: 31541-32-9
• Molecular Formula: C16H13NO3
• Molecular Weight: 267.284
• Mol file: 31541-32-9.mol

Synonyms:1-(4-Methoxy-benzyl)-1H-indole-2,3-dione;1-(4-METHOXYBENZYL)-1H-INDOLE-2,3-DIONE;1-(4-methoxybenzyl)indolin-2,3-dione;1-(4-methoxybenzyl)isatin;N-PMB-isatin;1-(4-methoxybenzyl)indoline-2,3-dione;PMB-isatin;

Chemical Property of 1-(4-METHOXYBENZYL)-1H-INDOLE-2,3-DIONE

Chemical Property:

• PSA: 46.61000
• LogP: 2.48970

Purity/Quality:

99% ^*data from raw suppliers

1-(4-Methoxybenzyl)indoline-2,3-dione 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-METHOXYBENZYL)-1H-INDOLE-2,3-DIONE

There total 11 articles about 1-(4-METHOXYBENZYL)-1H-INDOLE-2,3-DIONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

indole-2,3-dione (91-56-5,1186480-61-4,84788-92-1) + p-methoxybenzyl chloride (824-94-2) → 1-(4-methoxybenzyl)-1H-indole-2,3-dione (31541-32-9)

Guidance literature:

indole-2,3-dione; With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 0 ℃; Inert atmosphere;

p-methoxybenzyl chloride; In N,N-dimethyl-formamide; at 110 ℃; for 3h; Inert atmosphere;

DOI:10.1021/ol901432a

Reference yield: 95.0%

N-(4-methoxyphenyl)-N-methyl-2-oxo-acetamide → 1-(4-methoxybenzyl)-1H-indole-2,3-dione (31541-32-9)

Guidance literature:

With palladium dichloride; In dimethyl sulfoxide; at 100 ℃; for 3h;

DOI:10.1039/c5ra23837d

Reference yield: 91.0%

2-hydroxy-N-(4-methoxybenzyl)-N-phenylacetamide → 1-(4-methoxybenzyl)-1H-indole-2,3-dione (31541-32-9)

Guidance literature:

With ruthenium trichloride; dimethyl sulfoxide; at 100 ℃; for 5h;

DOI:10.1016/j.tet.2016.04.041

upstream raw materials:

indole-2,3-dione

p-methoxybenzyl chloride

p-Methoxybenzyl bromide

1-(2-((4-methoxybenzyl)amino)phenyl)ethan-1-one

Downstream raw materials:

(R)-3-(2-(tert-butyldimethylsilyloxy)-1-phenylethylimino)-1-(4-methoxybenzyl)indolin-2-one

(R)-N-(1-(4-methoxybenzyl)-2-oxoindolin-3-ylidene)-2-methylpropane-2-sulfinamide

C₁₈H₁₇NO₃

(R)-3-hydroxy-3-(2-hydroxyethyl)-1-(4-methoxybenzyl)indolin-2-one

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