(R)-3-(2-(tert-butyldimethylsilyloxy)-1-phenylethylimino)-1-(4-methoxybenzyl)indolin-2-one

Base Information

Chemical Name:(R)-3-(2-(tert-butyldimethylsilyloxy)-1-phenylethylimino)-1-(4-methoxybenzyl)indolin-2-one
CAS No.:1160027-93-9
Molecular Formula:C₃₀H₃₆N₂O₃Si
Molecular Weight:500.713
Hs Code.:

Synonyms:(R)-3-(2-(tert-butyldimethylsilyloxy)-1-phenylethylimino)-1-(4-methoxybenzyl)indolin-2-one

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Chemical Property of (R)-3-(2-(tert-butyldimethylsilyloxy)-1-phenylethylimino)-1-(4-methoxybenzyl)indolin-2-one

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Technology Process of (R)-3-(2-(tert-butyldimethylsilyloxy)-1-phenylethylimino)-1-(4-methoxybenzyl)indolin-2-one

There total 1 articles about (R)-3-(2-(tert-butyldimethylsilyloxy)-1-phenylethylimino)-1-(4-methoxybenzyl)indolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 31541-32-9
1-(4-methoxybenzyl)-1H-indole-2,3-dione

: 120417-13-2,120666-55-9
(1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-phenylethanamine

: 1160027-93-9
(R)-3-(2-(tert-butyldimethylsilyloxy)-1-phenylethylimino)-1-(4-methoxybenzyl)indolin-2-one

Guidance literature:: With magnesium sulfate; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1021/jo900623c

Reference yield: 77.0%

: 1160027-93-9
(R)-3-(2-(tert-butyldimethylsilyloxy)-1-phenylethylimino)-1-(4-methoxybenzyl)indolin-2-one

: 1730-25-2
allylmagnesium bromide

: 1160028-04-5
(S)-3-allyl-3-((R)-2-(tert-butyldimethylsilyloxy)-1-phenylethylamino)-1-(4-methoxybenzyl)indolin-2-one

: (R)-3-allyl-3-((R)-2-(tert-butyldimethylsilyloxy)-1-phenylethylamino)-1-(4-methoxybenzyl)indolin-2-one

Guidance literature:: (R)-3-(2-(tert-butyldimethylsilyloxy)-1-phenylethylimino)-1-(4-methoxybenzyl)indolin-2-one; With magnesium bromide; In dichloromethane; at -40 ℃; for 0.333333h; Inert atmosphere;

allylmagnesium bromide; In dichloromethane; at -40 - 20 ℃; Inert atmosphere;

With water; ammonium chloride; In dichloromethane; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/jo900623c

Reference yield: 62.0%

: 1160027-93-9
(R)-3-(2-(tert-butyldimethylsilyloxy)-1-phenylethylimino)-1-(4-methoxybenzyl)indolin-2-one

: 13139-86-1
4-methoxyphenyl magnesium bromide

: (R)-3-((R)-2-(tert-butyldimethylsilyloxy)-1-phenylethylamino)-1-(4-methoxybenzyl)-3-(4-methoxybenzyl)indolin-2-one

: (S)-3-((R)-2-(tert-butyldimethylsilyloxy)-1-phenylethylamino)-1-(4-methoxybenzyl)-3-(4-methoxybenzyl)indolin-2-one

Guidance literature:: (R)-3-(2-(tert-butyldimethylsilyloxy)-1-phenylethylimino)-1-(4-methoxybenzyl)indolin-2-one; With magnesium bromide; In dichloromethane; at -40 ℃; for 0.333333h; Inert atmosphere;

4-methoxyphenyl magnesium bromide; In dichloromethane; at -40 - 20 ℃; Inert atmosphere;

With water; ammonium chloride; In dichloromethane; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/jo900623c