Phenyl(5-phenyl-1,3-oxazol-2-yl)methanone

Base Information

• Chemical Name: Phenyl(5-phenyl-1,3-oxazol-2-yl)methanone
• CAS No.: 31970-74-8
• Molecular Formula: C16H11NO2
• Molecular Weight: 249.269
• DSSTox Substance ID: DTXSID90537956
• Nikkaji Number: J1.209.719K
• Wikidata: Q82413141
• Mol file: 31970-74-8.mol

Synonyms:31970-74-8;Phenyl(5-phenyloxazol-2-yl)methanone;Phenyl(5-phenyl-1,3-oxazol-2-yl)methanone;DTXSID90537956

Chemical Property of Phenyl(5-phenyl-1,3-oxazol-2-yl)methanone

Chemical Property:

• XLogP3: 3.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 249.078978594
• Heavy Atom Count: 19
• Complexity: 306

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CN=C(O2)C(=O)C3=CC=CC=C3

Technology Process of Phenyl(5-phenyl-1,3-oxazol-2-yl)methanone

There total 31 articles about Phenyl(5-phenyl-1,3-oxazol-2-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-benzyl-5-phenyl-oxazole (68395-81-3) → phenyl(5-phenyloxazol-2-yl)methanone (31970-74-8)

Guidance literature:

With water; iodine; trifluoroacetic acid; In N,N-dimethyl-formamide; at 120 ℃; for 24h;

DOI:10.1002/adsc.201701130

Reference yield: 93.0%

phenyl(5-phenyloxazol-2-yl)methanol → phenyl(5-phenyloxazol-2-yl)methanone (31970-74-8)

Guidance literature:

With iodine; trifluoroacetic acid; In N,N-dimethyl-formamide; at 120 ℃; for 24h; Reagent/catalyst;

DOI:10.1002/adsc.201701130

Reference yield: 90.0%

5-phenyloxazole (1006-68-4) + benzoyl fluoride (455-32-3) → phenyl(5-phenyloxazol-2-yl)methanone (31970-74-8)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; triphenylphosphine; copper(l) chloride; In toluene; at 80 ℃; for 24h; Reagent/catalyst; Glovebox; Sealed tube;

DOI:10.1002/chem.201901219

upstream raw materials:

phenyl(5-phenyl-1,2-oxazol-3-yl)methanone

5-phenyloxazole

N-(pyridin-2-yl)-N-methylbenzamide

benzoyl chloride