N'-Methylbenzohydrazide--hydrogen chloride (1/1)

Base Information

• Chemical Name: N'-Methylbenzohydrazide--hydrogen chloride (1/1)
• CAS No.: 1483-23-4
• Molecular Formula: C8H10 N2 O . Cl H
• Molecular Weight: 150.1778
• DSSTox Substance ID: DTXSID10494956
• NSC Number: 79065
• Mol file: 1483-23-4.mol

Synonyms:1483-23-4;N'-Methylbenzohydrazide--hydrogen chloride (1/1);DTXSID10494956;NSC79065;NSC-79065

Chemical Property of N'-Methylbenzohydrazide--hydrogen chloride (1/1)

Chemical Property:

• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 186.0559907
• Heavy Atom Count: 12
• Complexity: 130

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNNC(=O)C1=CC=CC=C1.Cl

Technology Process of N'-Methylbenzohydrazide--hydrogen chloride (1/1)

There total 4 articles about N'-Methylbenzohydrazide--hydrogen chloride (1/1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(phenyl-[1,3,4]oxadiazol-2-ylmercapto)-acetic acid amide → benzoic acid-(N'-methyl-hydrazide); hydrochloride (1483-23-4)

Guidance literature:

(phenyl-[1,3,4]oxadiazol-2-ylmercapto)-acetic acid amide; With sodium tetrahydroborate; acetic acid; In 1,4-dioxane; at 10 ℃; Reflux;

With hydrogenchloride; In chloroform;

DOI:10.2174/157017810791514670

Reference yield:

benzoic acid hydrazide (613-94-5) → benzoic acid-(N'-methyl-hydrazide); hydrochloride (1483-23-4)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium hydroxide / ethanol

2: sodium hydrogencarbonate / water

3: ammonia / ethanol

4: sodium tetrahydroborate; acetic acid / 1,4-dioxane / 10 °C / Reflux

With sodium tetrahydroborate; ammonia; sodium hydrogencarbonate; acetic acid; potassium hydroxide; In 1,4-dioxane; ethanol; water;

DOI:10.2174/157017810791514670

Reference yield:

(phenyl-[1,3,4]oxadiazol-2-ylmercapto)-acetic acid ethyl ester (104496-93-7) → benzoic acid-(N'-methyl-hydrazide); hydrochloride (1483-23-4)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonia / ethanol

2: sodium tetrahydroborate; acetic acid / 1,4-dioxane / 10 °C / Reflux

With sodium tetrahydroborate; ammonia; acetic acid; In 1,4-dioxane; ethanol;

DOI:10.2174/157017810791514670

upstream raw materials:

(phenyl-[1,3,4]oxadiazol-2-ylmercapto)-acetic acid ethyl ester

benzoic acid hydrazide

2-Mercapto-5-phenyl-1,3,4-oxadiazole

Downstream raw materials:

N-benzoyl-N'-methyl-N'-(4-chlorobenzenesulfonyl)hydrazine

N-benzoyl-N'-methyl-N'-(4-methylbenzenesulfonyl)hydrazine