Methyl 6-broMo-3-hydroxypicolinate

Base Information

• Chemical Name: Methyl 6-broMo-3-hydroxypicolinate
• CAS No.: 321601-48-3
• Molecular Formula: C7H6BrNO3
• Molecular Weight: 232.034
• Hs Code.: 2933399090
• Mol file: 321601-48-3.mol

Synonyms:methyl 6-bromo-3-hydroxy-2-pyridinecarboxylate;Methyl 6-bromo-3-hydroxypicolinate;6-bromo-3-hydroxypicolinic acid methyl ester;

Chemical Property of Methyl 6-broMo-3-hydroxypicolinate

Chemical Property:

• Boiling Point: 388.8±37.0 °C(Predicted)
• PKA: 3.49±0.10(Predicted)
• PSA: 59.42000
• Density: 1.716±0.06 g/cm3(Predicted)
• LogP: 1.33630
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

Methyl6-bromo-3-hydroxypicolinate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 6-broMo-3-hydroxypicolinate

There total 3 articles about Methyl 6-broMo-3-hydroxypicolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl 3-hydroxypicolinate (62733-99-7) → methyl 6-bromo-3-hydroxypyridine-2-carboxylate (321601-48-3)

Guidance literature:

With bromine; In water; at 0 ℃; regioselective reaction;

DOI:10.1016/j.jconrel.2018.10.010

Reference yield: 42.0%

methanol (67-56-1) + 3-hydroxypyridine-2-carboxylic acid (874-24-8) → methyl 6-bromo-3-hydroxypyridine-2-carboxylate (321601-48-3)

Guidance literature:

methanol; 3-hydroxypyridine-2-carboxylic acid; With diazomethyl-trimethyl-silane; In dichloromethane;

With bromine; In water;

DOI:10.1016/j.bmcl.2019.03.029

Reference yield:

3-hydroxypyridine-2-carboxylic acid (874-24-8) → methyl 6-bromo-3-hydroxypyridine-2-carboxylate (321601-48-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / 24 h / Reflux

2: bromine / water / 17 h / 0 - 20 °C

With sulfuric acid; bromine; In water;

DOI:10.1039/c4cc00561a

upstream raw materials:

methyl 3-hydroxypicolinate

3-hydroxypyridine-2-carboxylic acid

methanol

Downstream raw materials:

methyl 6-bromo-3-methoxypyridine-2-carboxylate

6-bromo-3-(3-phenoxy-propoxy)-pyridine-2-carboxylic acid methyl ester

methyl 3-(benzyloxy)-6-(5-(6,7-dimethoxy-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)pent-1-ynyl)picolinate

methyl 6-(5-(6,7-dimethoxy-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)pentyl)-3-hydroxypicolinate

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