5H-Pyrrolo[2,1-a]isoindol-5-one, 9-amino-1,2,3,9b-tetrahydro-

Base Information

Chemical Name:5H-Pyrrolo[2,1-a]isoindol-5-one, 9-amino-1,2,3,9b-tetrahydro-
CAS No.:322692-77-3
Molecular Formula:C11H12N2O
Molecular Weight:188.22600
Hs Code.:
DSSTox Substance ID:DTXSID50476514
Mol file:322692-77-3.mol

Synonyms:322692-77-3;5H-Pyrrolo[2,1-a]isoindol-5-one, 9-amino-1,2,3,9b-tetrahydro-;9-amino-1,2,3,9b-tetrahydropyrrolo[1,2-b]isoindol-5-one;SCHEMBL5666976;DTXSID50476514;IXDFDXDYYBLCON-UHFFFAOYSA-N;9-amino-1,2,3,9b-tetrahydro-5h-pyrrolo[2,1-a]isoindol-5-one

Suppliers and Price of 5H-Pyrrolo[2,1-a]isoindol-5-one, 9-amino-1,2,3,9b-tetrahydro-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AccelPharmtech
9-amino-1,2,3,9b-tetrahydro-5H-Pyrrolo[2,1-a]isoindol-5-one 97.00%
25G
$ 8510.00

AccelPharmtech
9-amino-1,2,3,9b-tetrahydro-5H-Pyrrolo[2,1-a]isoindol-5-one 97.00%
5G
$ 4530.00

AccelPharmtech
9-amino-1,2,3,9b-tetrahydro-5H-Pyrrolo[2,1-a]isoindol-5-one 97.00%
1G
$ 2640.00

Total 0 raw suppliers

Chemical Property of 5H-Pyrrolo[2,1-a]isoindol-5-one, 9-amino-1,2,3,9b-tetrahydro-

Chemical Property:

PSA：46.33000
LogP:2.07860
XLogP3:0.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:188.094963011
Heavy Atom Count:14
Complexity:266

Purity/Quality:: 9-amino-1,2,3,9b-tetrahydro-5H-Pyrrolo[2,1-a]isoindol-5-one 97.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC2C3=C(C=CC=C3N)C(=O)N2C1

Technology Process of 5H-Pyrrolo[2,1-a]isoindol-5-one, 9-amino-1,2,3,9b-tetrahydro-

There total 7 articles about 5H-Pyrrolo[2,1-a]isoindol-5-one, 9-amino-1,2,3,9b-tetrahydro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 322692-75-1
9-nitro-5H-pyrrolo[2,1-α]isoindol-5-one

: 322692-77-3
9-amino-1,2,3,9b-tetrahydro-5H-pyrrolo[2,1-α]isoindol-5-one

Guidance literature:: With hydrogen; 10percent Pd/C; In methanol; at 20 ℃; for 2h; under 760.051 Torr;
DOI:10.1021/jm0103256

Reference yield:

: 6286-36-8
2-bromo-3-nitrobenzoic acid chloride

: 322692-77-3
9-amino-1,2,3,9b-tetrahydro-5H-pyrrolo[2,1-α]isoindol-5-one

Guidance literature:: Multi-step reaction with 3 steps

1: 865 mg / Et₃N / CH₂Cl₂ / 10 h / 20 °C

2: 81 percent / Pd(PPh₃)4; KOAc / N,N-dimethyl-acetamide / 10 h / 130 °C

3: 99 percent / H₂ / 10percent Pd/C / methanol / 2 h / 20 °C / 760.05 Torr

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; potassium acetate; triethylamine; 10percent Pd/C; In methanol; dichloromethane; N,N-dimethyl acetamide;
DOI:10.1021/jm0103256

Reference yield:

: 573-54-6
2-bromo-3-nitro-benzoic acid

: 322692-77-3
9-amino-1,2,3,9b-tetrahydro-5H-pyrrolo[2,1-α]isoindol-5-one

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / 3 h / 80 °C

2: 865 mg / Et₃N / CH₂Cl₂ / 10 h / 20 °C

3: 81 percent / Pd(PPh₃)4; KOAc / N,N-dimethyl-acetamide / 10 h / 130 °C

4: 99 percent / H₂ / 10percent Pd/C / methanol / 2 h / 20 °C / 760.05 Torr

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; hydrogen; potassium acetate; triethylamine; 10percent Pd/C; In methanol; dichloromethane; N,N-dimethyl acetamide;
DOI:10.1021/jm0103256