tert-butyl 5-[(2S)-1-benzylpyrrolidin-2-yl]-3-({[(5-oxo-2,3,5,9b-tetrahydro-1H-pyrrolo[2,1-α]isoindol-9-yl)amino]carbonyl}amino)-1H-pyrazole-1-carboxylate

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Chemical Name:tert-butyl 5-[(2S)-1-benzylpyrrolidin-2-yl]-3-({[(5-oxo-2,3,5,9b-tetrahydro-1H-pyrrolo[2,1-α]isoindol-9-yl)amino]carbonyl}amino)-1H-pyrazole-1-carboxylate
CAS No.:1026942-51-7
Molecular Formula:C₃₁H₃₆N₆O₄
Molecular Weight:556.665
Hs Code.:

tert-butyl 5-[(2S)-1-benzylpyrrolidin-2-yl]-3-({[(5-oxo-2,3,5,9b-tetrahydro-1H-pyrrolo[2,1-α]isoindol-9-yl)amino]carbonyl}amino)-1H-pyrazole-1-carboxylate

Synonyms:tert-butyl 5-[(2S)-1-benzylpyrrolidin-2-yl]-3-({[(5-oxo-2,3,5,9b-tetrahydro-1H-pyrrolo[2,1-α]isoindol-9-yl)amino]carbonyl}amino)-1H-pyrazole-1-carboxylate

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Chemical Property of tert-butyl 5-[(2S)-1-benzylpyrrolidin-2-yl]-3-({[(5-oxo-2,3,5,9b-tetrahydro-1H-pyrrolo[2,1-α]isoindol-9-yl)amino]carbonyl}amino)-1H-pyrazole-1-carboxylate

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Technology Process of tert-butyl 5-[(2S)-1-benzylpyrrolidin-2-yl]-3-({[(5-oxo-2,3,5,9b-tetrahydro-1H-pyrrolo[2,1-α]isoindol-9-yl)amino]carbonyl}amino)-1H-pyrazole-1-carboxylate

There total 3 articles about tert-butyl 5-[(2S)-1-benzylpyrrolidin-2-yl]-3-({[(5-oxo-2,3,5,9b-tetrahydro-1H-pyrrolo[2,1-α]isoindol-9-yl)amino]carbonyl}amino)-1H-pyrazole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 7693-46-1
4-Nitrophenyl chloroformate

: 322692-77-3
9-amino-1,2,3,9b-tetrahydro-5H-pyrrolo[2,1-α]isoindol-5-one

: 322692-22-8
tert-butyl 3-amino-5-[(2S)-1-benzylpyrrolidin-2-yl]-1H-pyrazole-1-carboxylate

: 1026942-51-7
tert-butyl 5-[(2S)-1-benzylpyrrolidin-2-yl]-3-({[(5-oxo-2,3,5,9b-tetrahydro-1H-pyrrolo[2,1-α]isoindol-9-yl)amino]carbonyl}amino)-1H-pyrazole-1-carboxylate

Guidance literature:: tert-butyl 3-amino-5-[(2S)-1-benzylpyrrolidin-2-yl]-1H-pyrazole-1-carboxylate; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.5h;

4-Nitrophenyl chloroformate; In tetrahydrofuran; for 0.5h;

9-amino-1,2,3,9b-tetrahydro-5H-pyrrolo[2,1-α]isoindol-5-one; With dmap; In tetrahydrofuran; at 60 ℃; for 12h; Further stages.;
DOI:10.1021/jm010326y

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1026942-51-7
tert-butyl 5-[(2S)-1-benzylpyrrolidin-2-yl]-3-({[(5-oxo-2,3,5,9b-tetrahydro-1H-pyrrolo[2,1-α]isoindol-9-yl)amino]carbonyl}amino)-1H-pyrazole-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / dimethylformamide / 0.5 h / 20 °C

1.2: 61 percent / tetrahydrofuran; dimethylformamide / 0.5 h

2.1: NaH / tetrahydrofuran / 0.5 h / 20 °C

2.2: tetrahydrofuran / 0.5 h

2.3: 42 percent / 4-(dimethylamino)pyridine / tetrahydrofuran / 12 h / 60 °C

With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm010326y

Reference yield:

: 393590-66-4
5-[(2S)-1-benzyloxypyrrolidin-2-yl]-1H-pyrazol-3-amine

: 1026942-51-7
tert-butyl 5-[(2S)-1-benzylpyrrolidin-2-yl]-3-({[(5-oxo-2,3,5,9b-tetrahydro-1H-pyrrolo[2,1-α]isoindol-9-yl)amino]carbonyl}amino)-1H-pyrazole-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / dimethylformamide / 0.5 h / 20 °C

1.2: 61 percent / tetrahydrofuran; dimethylformamide / 0.5 h

2.1: NaH / tetrahydrofuran / 0.5 h / 20 °C

2.2: tetrahydrofuran / 0.5 h

2.3: 42 percent / 4-(dimethylamino)pyridine / tetrahydrofuran / 12 h / 60 °C

With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm010326y