1H-Pyrazole-1-carboxylic acid, 5-[(phenylmethoxy)methyl]-3-[[[(2,3,5,9b-tetrahydro-5-oxo-1H-pyrrolo[2, 1-a]isoindol-9-yl)amino]carbonyl]amino]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:1H-Pyrazole-1-carboxylic acid, 5-[(phenylmethoxy)methyl]-3-[[[(2,3,5,9b-tetrahydro-5-oxo-1H-pyrrolo[2, 1-a]isoindol-9-yl)amino]carbonyl]amino]-, 1,1-dimethylethyl ester
CAS No.:393590-65-3
Molecular Formula:C28H31N5O5
Molecular Weight:517.585
Hs Code.:
Mol file:393590-65-3.mol

1H-Pyrazole-1-carboxylic acid,
5-[(phenylmethoxy)methyl]-3-[[[(2,3,5,9b-tetrahydro-5-oxo-1H-pyrrolo[2,
1-a]isoindol-9-yl)amino]carbonyl]amino]-, 1,1-dimethylethyl ester

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Chemical Property of 1H-Pyrazole-1-carboxylic acid, 5-[(phenylmethoxy)methyl]-3-[[[(2,3,5,9b-tetrahydro-5-oxo-1H-pyrrolo[2, 1-a]isoindol-9-yl)amino]carbonyl]amino]-, 1,1-dimethylethyl ester

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Technology Process of 1H-Pyrazole-1-carboxylic acid, 5-[(phenylmethoxy)methyl]-3-[[[(2,3,5,9b-tetrahydro-5-oxo-1H-pyrrolo[2, 1-a]isoindol-9-yl)amino]carbonyl]amino]-, 1,1-dimethylethyl ester

There total 3 articles about 1H-Pyrazole-1-carboxylic acid, 5-[(phenylmethoxy)methyl]-3-[[[(2,3,5,9b-tetrahydro-5-oxo-1H-pyrrolo[2, 1-a]isoindol-9-yl)amino]carbonyl]amino]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7693-46-1
4-Nitrophenyl chloroformate

: 322692-77-3
9-amino-1,2,3,9b-tetrahydro-5H-pyrrolo[2,1-α]isoindol-5-one

: 393590-63-1
tert-butyl 3-amino-5-[(benzyloxy)methyl]-1H-pyrazole-1-carboxylate

: 393590-65-3
tert-butyl 5-[(benzyloxy)methyl]-3-({[(5-oxo-2,3,5,9b-tetrahydro-1H-pyrrolo[2,1-α]isoindol-9-yl)amino]carbonyl}amino)-1H-pyrazole-1-carboxylate

Guidance literature:: 4-Nitrophenyl chloroformate; tert-butyl 3-amino-5-[(benzyloxy)methyl]-1H-pyrazole-1-carboxylate; With dmap; In chloroform; at 70 ℃; for 0.5h;

9-amino-1,2,3,9b-tetrahydro-5H-pyrrolo[2,1-α]isoindol-5-one; In chloroform; at 70 ℃; for 2h; Further stages.;
DOI:10.1021/jm010326y

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 393590-65-3
tert-butyl 5-[(benzyloxy)methyl]-3-({[(5-oxo-2,3,5,9b-tetrahydro-1H-pyrrolo[2,1-α]isoindol-9-yl)amino]carbonyl}amino)-1H-pyrazole-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / tetrahydrofuran; dimethylformamide / 0.5 h / 0 °C

1.2: 53 percent / tetrahydrofuran; dimethylformamide / 2 h / 20 °C

2.1: 4-(dimethylamino)pyridine / CHCl₃ / 0.5 h / 70 °C

2.2: CHCl₃ / 2 h / 70 °C

With dmap; sodium hydride; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm010326y

Reference yield:

: 393590-62-0
5-[(benzyloxy)methyl]-1H-pyrazol-3-amine

: 393590-65-3
tert-butyl 5-[(benzyloxy)methyl]-3-({[(5-oxo-2,3,5,9b-tetrahydro-1H-pyrrolo[2,1-α]isoindol-9-yl)amino]carbonyl}amino)-1H-pyrazole-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / tetrahydrofuran; dimethylformamide / 0.5 h / 0 °C

1.2: 53 percent / tetrahydrofuran; dimethylformamide / 2 h / 20 °C

2.1: 4-(dimethylamino)pyridine / CHCl₃ / 0.5 h / 70 °C

2.2: CHCl₃ / 2 h / 70 °C

With dmap; sodium hydride; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm010326y