DIMETHYL 2,6-DIMETHYL-4-STYRYL-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE

Base Information

• Chemical Name: DIMETHYL 2,6-DIMETHYL-4-STYRYL-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE
• CAS No.: 324577-03-9
• Molecular Formula: C₁₉H₂₁NO₄
• Molecular Weight: 327.38
• Mol file: 324577-03-9.mol

Synonyms:

Chemical Property of DIMETHYL 2,6-DIMETHYL-4-STYRYL-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE

Chemical Property:

Purity/Quality:

DIMETHYL-2,6-DIMETHYL-4-STYRYL-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of DIMETHYL 2,6-DIMETHYL-4-STYRYL-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE

There total 5 articles about DIMETHYL 2,6-DIMETHYL-4-STYRYL-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(E)-3-phenylpropenal (14371-10-9) + acetoacetic acid methyl ester (105-45-3) → dimethyl 2,6-dimethyl-4-[(E)-2-phenylvinyl]-1,4-dihydropyridine-3,5-dicarboxylate (133595-50-3,324577-03-9)

Guidance literature:

With C₂₃H₃BF₁₆N₂O; ammonium acetate; In toluene; at 100 ℃; for 10h;

Reference yield: 95.0%

methoxy acetoacetate (105025-71-6) + 3-phenyl-propenal (104-55-2) → 2,6-dimethyl-4-styryl-1,4-dihydropyridine-3,5-dicarboxylic acid dimethyl ester (324577-03-9)

Guidance literature:

With ammonium acetate; In neat (no solvent); at 60 ℃; for 0.333333h;

DOI:10.1039/c3ta12476b

Reference yield: 95.0%

acetoacetic acid methyl ester (105-45-3) + 3-phenyl-propenal (104-55-2) → 2,6-dimethyl-4-styryl-1,4-dihydropyridine-3,5-dicarboxylic acid dimethyl ester (324577-03-9)

Guidance literature:

With ammonium acetate; In 2,2,2-trifluoroethanol; at 70 ℃; for 3h;

DOI:10.1016/j.jfluchem.2009.03.014

upstream raw materials:

(E)-3-phenylpropenal

methyl (E)-3-aminocrotonate

3-phenyl-propenal

acetoacetic acid methyl ester

Refernces

• 1、 Dekamin, Mohammad G.,Ilkhanizadeh, Siamand,Latifidoost, Zahra,Daemi, Hamed,Karimi, Zahra,Barikani, Mehdi. "Alginic acid: A highly efficient renewable and heterogeneous biopolymeric catalyst for one-pot synthesis of the Hantzsch 1,4-dihydropyridines". . p. 56658 - 56664. Retrieved 2015/02/02.
• 2、 Pramanik, Malay,Bhaumik, Asim. "Self-assembled hybrid tinphosphonate nanoparticles with bimodal porosity: An insight towards the efficient and selective catalytic process for the synthesis of bioactive 1,4-dihydropyridines under solvent-free conditions". . p. 11210 - 11220. Retrieved 2013/09/23.