Acetylamino-Thioacetic Acid S-[(Diphenylphosphanyl)-Methyl] Ester

Base Information

Chemical Name:Acetylamino-Thioacetic Acid S-[(Diphenylphosphanyl)-Methyl] Ester
CAS No.:324753-12-0
Molecular Formula:C17H18NO2PS
Molecular Weight:331.375
Hs Code.:
DSSTox Substance ID:DTXSID601191656
Nikkaji Number:J1.591.262F

Synonyms:SCHEMBL4851236;OOYLQGSQILCJKL-UHFFFAOYSA-N;DTXSID601191656;324753-12-0;S-[(Diphenylphosphino)methyl] 2-(acetylamino)ethanethioate;Acetylamino-Thioacetic Acid S-[(Diphenylphosphanyl)-Methyl] Ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Acetylamino-Thioacetic Acid S-[(Diphenylphosphanyl)-Methyl] Ester

Chemical Property:

XLogP3:2.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:7
Exact Mass:331.07958699
Heavy Atom Count:22
Complexity:348

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(=O)NCC(=O)SCP(C1=CC=CC=C1)C2=CC=CC=C2

Technology Process of Acetylamino-Thioacetic Acid S-[(Diphenylphosphanyl)-Methyl] Ester

There total 7 articles about Acetylamino-Thioacetic Acid S-[(Diphenylphosphanyl)-Methyl] Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 543-24-8
N-acetylglycine

: 324753-16-4
(diphenylphosphanyl)methanethiol

: 324753-12-0
(acetylamino)thioacetic acid S-[(diphenylphosphanyl)methyl] ester

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; for 3h;
DOI:10.1021/jo025631l DOI:10.1021/ja060484k

Reference yield:

: 324753-11-9
thioacetic acid S-[(diphenylphosphanyl)methyl] ester

: 324753-12-0
(acetylamino)thioacetic acid S-[(diphenylphosphanyl)methyl] ester

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / NaOH / methanol

2: 96 percent / HOBt; DCC / dimethylformamide / 3 h

With sodium hydroxide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jo025631l

Reference yield:

: 1806-49-1
diphenyl(chloromethyl)phosphine oxide

: 324753-12-0
(acetylamino)thioacetic acid S-[(diphenylphosphanyl)methyl] ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 85 percent / diisopropylethyl amine; triethyl amine / tetrahydrofuran / 24 h / Heating

2.1: 98 percent / trichlorosilane / CHCl₃ / 72 h

3.1: 74 percent / NaOH / methanol / 2 h

4.1: sodium hydride; N-methylmercapoacetamide thioester / tetrahydrofuran; dimethylformamide / 8 h

4.2: 91 percent / Merrifield resin / tetrahydrofuran; dimethylformamide / 6 h

With sodium hydroxide; N-(methylthio)-acetamid; trichlorosilane; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/ol006739v