(4s)-4-Ethyl-4-hydroxy-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione 6-oxide

Base Information

Chemical Name:(4s)-4-Ethyl-4-hydroxy-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione 6-oxide
CAS No.:86639-48-7
Molecular Formula:C20H16N2O5
Molecular Weight:364.357
Hs Code.:2942000000
NSC Number:106748
Wikidata:Q83002845
Mol file:86639-48-7.mol

Synonyms:Camptothecin 1-oxide;(4s)-4-ethyl-4-hydroxy-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione 6-oxide;86639-48-7;(19S)-19-ethyl-19-hydroxy-3-oxido-17-oxa-13-aza-3-azoniapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione;Camptothecin N-oxide;NSC106748;SCHEMBL1109749;NSC-106748;1H-Pyrano[3',7]indolizino[1,2-b]quinoline-3,14(4H,12H)- dione, 4-ethyl-4-hydroxy-, 6-oxide-, (S)-

Suppliers and Price of (4s)-4-Ethyl-4-hydroxy-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione 6-oxide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 6 raw suppliers

Chemical Property of (4s)-4-Ethyl-4-hydroxy-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione 6-oxide

Chemical Property:

Boiling Point:809.2±75.0 °C(Predicted)
PKA:11.03±0.20(Predicted)
Flash Point:443.2oC
PSA：93.99000
Density:1.55±0.1 g/cm3(Predicted)
LogP:2.11310
XLogP3:0
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:364.10592162
Heavy Atom Count:27
Complexity:774

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=CC=CC=C5[N+](=C4C3=C2)[O-])O
Isomeric SMILES:CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=CC5=CC=CC=C5[N+](=C4C3=C2)[O-])O

Technology Process of (4s)-4-Ethyl-4-hydroxy-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione 6-oxide

There total 2 articles about (4s)-4-Ethyl-4-hydroxy-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione 6-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.46%

: 7689-03-4,91926-09-9
camptothecin

: 86639-48-7
Camptothecin 1-oxide

Guidance literature:: With sodium perborate; acetic acid; at 30 - 90 ℃; for 0.833333h;

Reference yield:

: 53544-22-2,142696-57-9,142696-58-0
1,2,6,7-tetrahydrocamptothecin

: 86639-48-7
Camptothecin 1-oxide

Guidance literature:: Multi-step reaction with 2 steps

1: 12 percent / Pb(OAc)4, trifluoroacetic acid / 0.25 h / Ambient temperature

2: 90.6 percent / 30percent aq. H₂O₂, acetic acid / 3.5 h / 70 - 80 °C

With lead(IV) acetate; dihydrogen peroxide; acetic acid; trifluoroacetic acid;
DOI:10.1248/cpb.39.3183