10-Methoxycamptothecin

Base Information

Chemical Name:10-Methoxycamptothecin
CAS No.:19685-10-0
Molecular Formula:C21H18 N2 O5
Molecular Weight:378.384
Hs Code.:
NSC Number:111533
DSSTox Substance ID:DTXSID60941445
Nikkaji Number:J258.664I
Wikidata:Q72489417
ChEMBL ID:CHEMBL75854
Mol file:19685-10-0.mol

Synonyms:9-methoxycamptothecin

Suppliers and Price of 10-Methoxycamptothecin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
9-Methoxycamptothecin
20mg
$ 390.00

JR MediChem
10-Methoxycamptothecine 98%
20mg
$ 700.00

DC Chemicals
10-Methoxycamptothecine >98%,StandardReferencesGrade
20 mg
$ 280.00

ChemScene
10-Methoxycamptothecin
10mg
$ 95.00

ChemScene
10-Methoxycamptothecin
5mg
$ 55.00

ChemScene
10-Methoxycamptothecin
25mg
$ 170.00

Biorbyt Ltd
9-Methoxycamptothecin 98%
20 mg
$ 306.00

Biorbyt Ltd
10-Methoxycamptothecine >98%,Standard References Grade
20 mg
$ 569.50

AvaChem
10-Methoxycamptothecin
100mg
$ 1490.00

AvaChem
10-Methoxycamptothecin
25mg
$ 490.00

Total 29 raw suppliers

Chemical Property of 10-Methoxycamptothecin

Chemical Property:

Vapor Pressure:3.78E-25mmHg at 25°C
Melting Point:254-255℃
Boiling Point:773.1°Cat760mmHg
PKA:11.21±0.20(Predicted)
Flash Point:421.4°C
PSA：90.65000
Density:1.5g/cm³
LogP:2.08820
XLogP3:1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:378.12157168
Heavy Atom Count:28
Complexity:790

Purity/Quality:

99%, ^*data from raw suppliers

9-Methoxycamptothecin ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=CC5=C4)OC)O
Isomeric SMILES:CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=CC5=C4)OC)O
Description A minor constituent of Mappia foetida Miers. The alkaloid yields pale yellow crystals when purified from CHC13-MeOH. It is laevorotatory with [α]24D - 77.5° (c 1.0, pyridine). The structure has been established by spectroscopic methods.
Uses 10-Methoxycamptothecin is a Camptothecin (C175150) derivative used in the treatment of cancers. Used in the treatment of hyperproliferative diseases. 9-Methoxycamptothecin is an alkaloid derivative of Camptothecin (C175150) derivative used in the treatment of cancers. Camptothecin is a potent anti-cancer agent.

Technology Process of 10-Methoxycamptothecin

There total 55 articles about 10-Methoxycamptothecin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 19685-09-7,64439-81-2
(S)-10-hydroxycamptothecin

: 19685-10-0
10-methoxycamptothecin

Guidance literature:: In 1,4-dioxane; methanol; at 20 ℃; for 2h;
DOI:10.1016/j.tetlet.2010.09.130

Reference yield: 85.0%

: 10349-38-9
p-methoxyphenylisonitrile

: 174092-80-9
(S)-4-ethyl-4-hydroxy-6-iodo-7-(prop-2-yn-1-yl)-1,7-dihydro-3H-pyrano[3,4-c]pyridino-3,8(4H)-dione

: 19685-10-0
10-methoxycamptothecin

Guidance literature:: With tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; potassium carbonate; triethylamine; In acetonitrile; at 20 ℃; for 24h; Inert atmosphere; Schlenk technique; Irradiation;
DOI:10.1002/cjoc.201800358

Reference yield: 82.0%

: 1088402-95-2
10-methoxy-21-hydroxycamptothecin

: 19685-10-0
10-methoxycamptothecin

Guidance literature:: With iodine; calcium carbonate; In methanol; water; at 40 ℃; for 24h; optical yield given as %ee; Inert atmosphere;
DOI:10.1021/ol802250y