Phosphonic acid, [difluoro(phenylseleno)methyl]-, diethyl ester

Base Information

• Chemical Name: Phosphonic acid, [difluoro(phenylseleno)methyl]-, diethyl ester
• CAS No.: 327156-99-0
• Molecular Formula: C11H15F2O3PSe
• Molecular Weight: 343.169
• DSSTox Substance ID: DTXSID40462103
• Nikkaji Number: J1.619.751C
• Wikidata: Q82286592

Synonyms:327156-99-0;Phosphonic acid, [difluoro(phenylseleno)methyl]-, diethyl ester;DTXSID40462103;Diethyl (difluoro(phenylselanyl)methyl)phosphonate

Chemical Property of Phosphonic acid, [difluoro(phenylseleno)methyl]-, diethyl ester

Chemical Property:

• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 7
• Exact Mass: 343.98921
• Heavy Atom Count: 18
• Complexity: 286

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOP(=O)(C(F)(F)[Se]C1=CC=CC=C1)OCC

Technology Process of Phosphonic acid, [difluoro(phenylseleno)methyl]-, diethyl ester

There total 2 articles about Phosphonic acid, [difluoro(phenylseleno)methyl]-, diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

Diethyl difluoromethylphosphonate (1478-53-1) + diphenyl diselenide (1666-13-3) → diethyl α,α-difluoromethyl-α-(phenylseleno)phosphonate (327156-99-0)

Guidance literature:

With lithium diisopropyl amide; at -78 ℃;

DOI:10.1021/ol006746j

Reference yield: 71.0%

Phenylselenyl chloride (5707-04-0) + Diethyl difluoromethylphosphonate (1478-53-1) → diethyl α,α-difluoromethyl-α-(phenylseleno)phosphonate (327156-99-0)

Guidance literature:

Diethyl difluoromethylphosphonate; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 0.25h;

Phenylselenyl chloride; In tetrahydrofuran; hexane; at -78 - 20 ℃;

DOI:10.1021/jo051511c

Reference yield: 82.0%

methylenecyclohexane (1192-37-6) + diethyl α,α-difluoromethyl-α-(phenylseleno)phosphonate (327156-99-0) → O,O-diethyl 2-cyclohexyl-1,1-difluoroethylphosphonate (141642-62-8)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; for 12h; Heating;

DOI:10.1021/jo051511c

upstream raw materials:

Diethyl difluoromethylphosphonate

diphenyl diselenide

Phenylselenyl chloride

Downstream raw materials:

O,O-diethyl 2-cyclohexyl-1,1-difluoroethylphosphonate

diethyl α,α-difluoromethyl-α-(phenyl)phosphonate

O,O-diethyl (phenylselanyl)(difluoromethyl)phosphonothioate

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