Phosphonic acid, P-(difluorophenylmethyl)-, diethyl ester

Base Information

Chemical Name:Phosphonic acid, P-(difluorophenylmethyl)-, diethyl ester
CAS No.:174349-94-1
Molecular Formula:C₁₁H₁₅F₂O₃P
Molecular Weight:264.209
Hs Code.:
DSSTox Substance ID:DTXSID801263823
Nikkaji Number:J724.608K

Synonyms:Phosphonic acid, P-(difluorophenylmethyl)-, diethyl ester;174349-94-1;SCHEMBL5795784;QUBGHLWVGKRUCV-UHFFFAOYSA-N;DTXSID801263823;Diethyl P-(difluorophenylmethyl)phosphonate;(alpha,alpha-Difluorobenzyl)phosphonic acid diethyl ester

Suppliers and Price of Phosphonic acid, P-(difluorophenylmethyl)-, diethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Phosphonic acid, P-(difluorophenylmethyl)-, diethyl ester

Chemical Property:

XLogP3:2.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:264.07268766
Heavy Atom Count:17
Complexity:268

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOP(=O)(C(C1=CC=CC=C1)(F)F)OCC

Technology Process of Phosphonic acid, P-(difluorophenylmethyl)-, diethyl ester

There total 16 articles about Phosphonic acid, P-(difluorophenylmethyl)-, diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 65094-22-6
diethyl (bromodifluoromethyl)phosphonate

: 98-80-6
phenylboronic acid

: 174349-94-1
diethyl α,α-difluoromethyl-α-(phenyl)phosphonate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 80 ℃; for 24h; Reagent/catalyst; Solvent; Schlenk technique; Inert atmosphere;
DOI:10.1002/anie.201309535

Reference yield: 82.0%

: 73778-49-1
diethylphosphonate

: diethyl α-fluoro-α-(phenylthio)benzylphosphonate

: 174349-94-1
diethyl α,α-difluoromethyl-α-(phenyl)phosphonate

Guidance literature:: With tetraethylammonium fluoride; In 1,2-dimethoxyethane; at 20 ℃; Further Variations:; Solvents; Product distribution; Electrochemical reaction;
DOI:10.1055/s-2007-977439

Reference yield: 80.0%

: 591-50-4
iodobenzene

: 65094-22-6
diethyl (bromodifluoromethyl)phosphonate

: 174349-94-1
diethyl α,α-difluoromethyl-α-(phenyl)phosphonate

Guidance literature:: diethyl (bromodifluoromethyl)phosphonate; With cadmium; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

iodobenzene; With copper(l) chloride; In N,N-dimethyl-formamide; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.jfluchem.2013.04.008