2-Methylsulfinylethanol

Base Information

• Chemical Name: 2-Methylsulfinylethanol
• CAS No.: 21281-74-3
• Molecular Formula: C3H8O2S
• Molecular Weight: 108.161
• NSC Number: 190406
• DSSTox Substance ID: DTXSID80307221
• Nikkaji Number: J337.014C
• Mol file: 21281-74-3.mol

Synonyms:21281-74-3;2-methylsulfinylethanol;(R)-2-(Methylsulfinyl)ethan-1-ol;2-(Methylsulfinyl)ethanol;(S)-2-(METHYLSULFINYL)ETHANOL;NSC190406;2-methylsulfinyl-ethanol;2-(Methylsulfinyl)ethanol #;SCHEMBL193367;Methyl 2-hydroxyethyl sulfoxide;DTXSID80307221;NSC-190406

Chemical Property of 2-Methylsulfinylethanol

Chemical Property:

• Vapor Pressure: 8.59E-06mmHg at 25°C
• Boiling Point: 335.1°C at 760 mmHg
• Flash Point: 156.4°C
• Density: 1.271g/cm³
• XLogP3: -1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 108.02450067
• Heavy Atom Count: 6
• Complexity: 52.8

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CS(=O)CCO

Technology Process of 2-Methylsulfinylethanol

There total 8 articles about 2-Methylsulfinylethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-methylmercapto-ethanol (5271-38-5) → 2-hydroxyethyl methyl sulfoxide (21281-74-3)

Guidance literature:

With oxovanadium(IV) sulfate; sodium phosphite; dihydrogen peroxide; In acetonitrile; at 20 ℃; for 1h;

DOI:10.1016/j.tetlet.2006.09.065

Reference yield:

sulfure de methyle et de 2-chloroethyle (542-81-4) → 1-Chloro-2-(methylsulphinyl)ethane (5331-57-7) + 2-hydroxyethyl methyl sulfoxide (21281-74-3)

Guidance literature:

With dimethyl sulfoxide; at 70 ℃; for 14h; Title compound not separated from byproducts;

DOI:10.1021/jo00300a036

Reference yield:

methanol (67-56-1) + 1-Chloro-2-(methylsulphinyl)ethane (5331-57-7) → 2-hydroxyethyl methyl sulfoxide (21281-74-3) + 1-methanesulfinyl-2-methoxy-ethane (73143-59-6)

Guidance literature:

With alkali hydroxide;

DOI:10.1021/ja01157a004

upstream raw materials:

methanol

1-Chloro-2-(methylsulphinyl)ethane

sulfure de methyle et de 2-chloroethyle

1-bromo-2-(methylsulphanyl)ethane

Downstream raw materials:

2-methylmercapto-ethanol

Acetic acid 2-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-methylsulfanyl-ethyl ester

Refernces

• 1、 Hsu, Fu-Lian,Szafraniec, Linda L.,Beaudry, William T.,Yang, Yu-Chu. "Oxidation of 2-Chloroethyl Sulfides to Sulfoxides by Dimethyl Sulfoxide". . p. 4153 - 4155. Retrieved 1990.
• 2、 Vasil'eva,Lisina. "Synthesis and radioprotective activity of functionally-substituted methyl(alkyl)sulfoxides". . p. 593 - 596. Retrieved 1998.
• 3、 Veisi, Hojat,Rashtiani, Asra,Rostami, Amin,Shirinbayan, Mohadeseh,Hemmati, Saba. "Chemo-selective oxidation of sulfide to sulfoxides with H2O2 catalyzed by oxo-vanadium/Schiff-base complex immobilized on modified magnetic Fe3O4 nanoparticles as a heterogeneous and recyclable nanocatalyst". . p. 358 - 366. Retrieved 2019.
• 4、 Hajjami, Maryam,Sheikhaei, Shiva,Gholamian, Fatemeh,Yousofvand, Zakieh. "Synthesis and Characterization of Magnetic Functionalized Ni and Cu Nano Catalysts and Their Application in Oxidation, Oxidative Coupling and Various Multi-Component Reactions". . p. 2420 - 2435. Retrieved 2021/01/04.
• 5、 Nikoorazm, Mohsen,Khanmoradi, Maryam. "Synthesis and characterization of VO–vanillin complex immobilized on MCM-41 and its facile catalytic application in the sulfoxidation reaction, and synthesis of 2,3-dihydroquinazolin-4(1H)-ones and disulfides in green media". . p. 1477 - 1489. Retrieved 2020/03/11.