Benzoxazole, 2-(4-methoxyphenyl)-6-nitro-

Base Information

• Chemical Name: Benzoxazole, 2-(4-methoxyphenyl)-6-nitro-
• CAS No.: 3315-22-8
• Molecular Formula: C14H10N2O4
• Molecular Weight: 270.244
• Mol file: 3315-22-8.mol

Synonyms:2-(4-Methoxy-phenyl)-6-nitro-benzooxazole;6-Nitro-2-(4-methoxyphenyl)-benzoxazol;

Chemical Property of Benzoxazole, 2-(4-methoxyphenyl)-6-nitro-

Chemical Property:

• Melting Point: 175 °C (benzene)
• PSA: 81.08000
• LogP: 3.93480

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzoxazole, 2-(4-methoxyphenyl)-6-nitro-

There total 6 articles about Benzoxazole, 2-(4-methoxyphenyl)-6-nitro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-{[1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-amino}-5-nitro-phenol → 2-(4-methoxy-phenyl)-6-nitro-benzooxazole (3315-22-8)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1016/S0040-4039(01)02302-4

Reference yield: 48.0%

6-nitrobenzo[d]oxazole (17200-30-5) + 4-methoxy-benzoyl chloride (100-07-2) → 2-(4-methoxy-phenyl)-6-nitro-benzooxazole (3315-22-8)

Guidance literature:

With hafnium-based metal-organic framework catalyst; In neat (no solvent); at 170 ℃; for 7h;

DOI:10.1016/j.jcat.2019.04.023

Reference yield:

5-Nitro-2-aminophenol (121-88-0) → 2-(4-methoxy-phenyl)-6-nitro-benzooxazole (3315-22-8)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / Heating

2: 91 percent / DDQ / CH₂Cl₂ / 0.5 h / 20 °C

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In ethanol; dichloromethane;

DOI:10.1016/S0040-4039(01)02302-4

upstream raw materials:

5-nitro-2-anisalamino-phenol

4-methoxy-benzaldehyde

5-Nitro-2-aminophenol

6-nitrobenzo[d]oxazole