1H-Inden-1-one, 2,3-dihydro-6-(4-methoxyphenyl)-2-[(4-methoxyphenyl)methyl]-4-(phenyl methyl)-

Base Information

• Chemical Name: 1H-Inden-1-one, 2,3-dihydro-6-(4-methoxyphenyl)-2-[(4-methoxyphenyl)methyl]-4-(phenyl methyl)-
• CAS No.: 331816-32-1
• Molecular Formula: C31H28O3
• Molecular Weight: 448.562
• Mol file: 331816-32-1.mol

Synonyms:

Chemical Property of 1H-Inden-1-one, 2,3-dihydro-6-(4-methoxyphenyl)-2-[(4-methoxyphenyl)methyl]-4-(phenyl methyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1H-Inden-1-one, 2,3-dihydro-6-(4-methoxyphenyl)-2-[(4-methoxyphenyl)methyl]-4-(phenyl methyl)-

There total 15 articles about 1H-Inden-1-one, 2,3-dihydro-6-(4-methoxyphenyl)-2-[(4-methoxyphenyl)methyl]-4-(phenyl methyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

(E)-4-benzyl-6-(4-methoxybenzylidene)-6-(4-methoxyphenyl)-indan-1-one (391864-73-6) → 4-benzyl-2-(4-methoxybenzyl)-6-(4-methoxy-phenyl)-indan-1-one (331816-32-1)

Guidance literature:

With hydrogen; Adam’s catalyst; In ethanol; ethyl acetate; at 20 ℃; for 15h;

DOI:10.1016/S0040-4020(01)00980-2

Reference yield:

4-benzyl-6-(4-methoxy-phenyl)-indan-1-one (331816-30-9) → 4-benzyl-2-(4-methoxybenzyl)-6-(4-methoxy-phenyl)-indan-1-one (331816-32-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / 2.5M aq. NaOH / ethanol / 24 h / 20 °C

2: 70 percent / H₂ / Pt₂O / ethanol; ethyl acetate / 15 h / 20 °C

With sodium hydroxide; hydrogen; Adam’s catalyst; In ethanol; ethyl acetate;

DOI:10.1016/S0040-4020(01)00980-2

Reference yield:

4-methoxyphenylboronic acid (5720-07-0) → 4-benzyl-2-(4-methoxybenzyl)-6-(4-methoxy-phenyl)-indan-1-one (331816-32-1)

Guidance literature:

Multi-step reaction with 9 steps

1.1: 99 percent / Pd(PPh₃)4; 2M aq. Na₂CO₃ / benzene; methanol / 17 h / 80 °C

2.1: TMEDA; sec-BuLi / tetrahydrofuran / 1.17 h / -78 °C

2.2: 80 percent / toluene / 12 h / Heating

3.1: 90 percent / DIBAL / CH₂Cl₂; hexane / 0.5 h / -78 °C

4.1: 95 percent / benzene / 1 h / 80 °C

5.1: 94 percent / H₂ / 10 percent Pd/C / ethanol / 36 h / 20 °C

6.1: SOCl₂ / CH₂Cl₂ / 3 h / 60 °C

7.1: TiCl₄ / CH₂Cl₂ / 12 h / 0 - 5 °C

8.1: 74 percent / 2.5M aq. NaOH / ethanol / 24 h / 20 °C

9.1: 70 percent / H₂ / Pt₂O / ethanol; ethyl acetate / 15 h / 20 °C

With sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; N,N,N,N,-tetramethylethylenediamine; hydrogen; sec.-butyllithium; titanium tetrachloride; diisobutylaluminium hydride; sodium carbonate; palladium on activated charcoal; Adam’s catalyst; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; ethyl acetate; benzene; 1.1: Suzuki-coupling conditions / 4.1: Wittig reaction / 7.1: Friedel-Crafts;

DOI:10.1016/S0040-4020(01)00980-2

upstream raw materials:

(E)-4-benzyl-6-(4-methoxybenzylidene)-6-(4-methoxyphenyl)-indan-1-one

4-methoxyphenylboronic acid

4-bromo-N,N-diethylbenzamide

N,N-diethyl-4′-methoxy-[1,1′-biphenyl]-4-carboxamide

Downstream raw materials:

4-benzyl-2-(4-hydroxybenzyl)-2-hydroxymethyl-6-(4-hydroxyphenyl)-indan-1-one