331816-30-9

Upstream product

• 331816-27-4 N,N-diethyl-4′-methoxy-[1,1′-biphenyl]-4-carboxamide 
• 331816-28-5 5-(4-methoxy-phenyl)-3-phenyl-3H-isobenzofuran-1-one 
• 395681-97-7 3-(3-benzyl-4'-methoxybiphenyl-4-yl)-propionic acid 
• 391864-70-3 3-[3-(hydroxy-phenyl-methyl)-4'-methoxy-biphenyl-4-yl]-acrylic acid benzyl ester 
• 15115-60-3 4-bromo-2,3-dihydroinden-1-one 
• 331816-33-2 5-(4-methoxy-phenyl)-3-phenyl-1,3-dihydro-isobenzofuran-1-ol 
• 5892-99-9 4-bromo-N,N-diethylbenzamide 
• 5720-07-0 4-methoxyphenylboronic acid 

Downstream Products

• 391864-73-6 (E)-4-benzyl-6-(4-methoxybenzylidene)-6-(4-methoxyphenyl)-indan-1-one 
• 331816-32-1 4-benzyl-2-(4-methoxybenzyl)-6-(4-methoxy-phenyl)-indan-1-one 
• 331816-26-3 4-benzyl-2-(4-hydroxybenzyl)-2-hydroxymethyl-6-(4-hydroxyphenyl)-indan-1-one 

Relevant academic research and scientific papers

Chiral deaza-coelenterazine analogs for probing a substrate-binding site in the Ca2+-binding photoprotein aequorin

The Ca2+-binding photoprotein aequorin is a complex of apoAequorin (apoprotein) and (S)-2-peroxycoelenterazine. Aequorin can be regenerated by the incubation of apoAequorin with coelenterazine and molecular oxygen (O2). In this study

Chemical studies on the chiral indanone derivatives as the inhibitor of Renilla luciferase

The bioluminescence reaction of coelenterazine involves an oxidative process. To investigate the reaction mechanism, we synthesized three mechanism-based inhibitors with an indanone core structure. The inhibitors exhibited the competitive inhibition of the Renilla luciferase reaction. The (-)-4-benzyl-2-(4-hydroxybenzyl)-2-hydroxymethyl-6-(4-hydroxyphenyl)-indan- 1-one showed the significant enantio-selectivity of the inhibition and its absolute configuration was assigned as the R-configuration. These inhibitors could be useful probes to study the catalytic environment in the coelenterazine-luciferase reaction.