Methanone, (4-chloro-2-methylphenyl)phenyl-

Base Information

• Chemical Name: Methanone, (4-chloro-2-methylphenyl)phenyl-
• CAS No.: 33184-54-2
• Molecular Formula: C14H11ClO
• Molecular Weight: 230.694
• Mol file: 33184-54-2.mol

Synonyms:

Chemical Property of Methanone, (4-chloro-2-methylphenyl)phenyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methanone, (4-chloro-2-methylphenyl)phenyl-

There total 7 articles about Methanone, (4-chloro-2-methylphenyl)phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

benzoyl chloride (98-88-4) + 4-chloro-2-methylphenylboronic acid (209919-30-2) → (4-chloro-2-methylphenyl)(phenyl)methanone (33184-54-2)

Guidance literature:

With C₁₇H₁₆Br₂N₄Pd; potassium carbonate; In toluene; at 60 ℃; for 4h; Inert atmosphere;

DOI:10.1039/d1ra07231e

Reference yield: 92.0%

1-chloro-3-methylbenzene (108-41-8) + benzoyl chloride (98-88-4) → (4-chloro-2-methylphenyl)(phenyl)methanone (33184-54-2)

Guidance literature:

With aluminium dodecatungsten phosphate; at 60 - 70 ℃; for 3h;

DOI:10.1016/j.tet.2004.09.049

Reference yield: 76.0%

N-methoxy-N-methylbenzamide (6919-61-5) + 2-bromo-5-chlorotoluene (14495-51-3) → (4-chloro-2-methylphenyl)(phenyl)methanone (33184-54-2)

Guidance literature:

2-bromo-5-chlorotoluene; With iodine; magnesium; In diethyl ether; for 1h; Heating;

N-methoxy-N-methylbenzamide; In diethyl ether; for 2h; Heating;

DOI:10.1016/j.tet.2005.09.143

upstream raw materials:

4-chloro-2-methylbenzoic acid

benzene

1-chloro-3-methylbenzene

benzoyl chloride

Downstream raw materials:

5-chloro-2-(phenylcarbonyl)benzoic acid

2-benzoyl-5-chloro-phenylacetonitrile

2-methyl-4-pyrrolidinobenzophenone

1-(2-methyl-4-pyrrolidinophenyl)-1-phenylprop-2-yn-1-ol