2-Ethoxy-2-phenylacetic acid

Base Information

• Chemical Name: 2-Ethoxy-2-phenylacetic acid
• CAS No.: 33224-99-6
• Molecular Formula: C10H12O3
• Molecular Weight: 180.203
• European Community (EC) Number: 830-506-4
• Mol file: 33224-99-6.mol

Synonyms:2-ethoxy-2-phenylacetic acid;33224-99-6;alpha-Ethoxyphenylacetic Acid;Benzeneacetic acid, a-ethoxy-;2-ethoxy-2-phenylaceticacid;SCHEMBL2553482;(RS)-Ethoxy-phenyl-acetic acid;2-ethoxy-2-phenyl-ethanoic acid;XBLYVSAKBBNYDO-UHFFFAOYSA-N;AC5916;MFCD09948905;AKOS000191885;AKOS016903950;SY057655;CS-0216698;EN300-54926;A836831;A913128;Z316258952

Chemical Property of 2-Ethoxy-2-phenylacetic acid

Chemical Property:

• XLogP3: 1.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 180.078644241
• Heavy Atom Count: 13
• Complexity: 162

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(C1=CC=CC=C1)C(=O)O

Technology Process of 2-Ethoxy-2-phenylacetic acid

There total 17 articles about 2-Ethoxy-2-phenylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-bromophenylacetic acid (4870-65-9,31302-84-8) + ethanol (64-17-5) → 2-ethoxy-2-phenylacetic acid (33224-99-6)

Guidance literature:

With sodium hydride; In tetrahydrofuran; mineral oil; at 10 - 20 ℃; for 1.5h; Inert atmosphere;

DOI:10.1021/op3001788

Reference yield: 92.0%

(R)-benzyl 2-ethoxy-2-phenylacetate → (R)-2-ethoxy-2-phenylacetic acid (33224-99-6)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; water; at 20 ℃; for 2h;

Reference yield: 89.0%

ethyl (R)-2-ethoxy-2-phenylacetate → (R)-2-ethoxy-2-phenylacetic acid (33224-99-6)

Guidance literature:

With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 20 ℃; for 1h;

upstream raw materials:

diethyl sulfate

MANDELIC ACID

2-bromophenylacetic acid

ethyl iodide

Downstream raw materials:

(diethoxymethyl)benzene

benzaldehyde

Ethoxy-phenyl-acetyl chloride

2-ethoxy-2-phenylethanenitrile