4-Hydroxy-2,6-diMethylnicotinic acid

Base Information

• Chemical Name: 4-Hydroxy-2,6-diMethylnicotinic acid
• CAS No.: 33259-21-1
• Molecular Formula: C8H9NO3
• Molecular Weight: 167.164
• Hs Code.: 2933399090
• Mol file: 33259-21-1.mol

Synonyms:4-hydroxy-2,6-dimethylpyridin-3-carboxylic acid;2,6-Dimethyl-4-hydroxy-pyridine-3-carboxylic-acid;4H-Thiopyran-4-thione,2,6-dimethyl;InChI=1/C7H8S2/c1-5-3-7(8)4-6(2)9-5/h3-4H,1-2H3;2,6-Dimethyl-4H-thiopyran-4-thion;4-Thioxo-2,6-dimethyl-thiapyran;2,6-Dimethyl-1-thia-4-thiopyron;2,6-dimethyl-thiopyran-4-thione;2,6-Dimethylthiopyran-4-thion;2,6-Dimethyl-4H-thiin-4-thion;4-Hydroxy-2,6-dimethylnicotinic acid;4-Hydroxy-2,6-dimethyl-nicotinsaeure;2,6-Dimethyl-4-hydroxy-3-pyridine-carboxylic-acid;

Chemical Property of 4-Hydroxy-2,6-diMethylnicotinic acid

Chemical Property:

• Melting Point: 257-258 °C
• Boiling Point: 448.9±45.0 °C(Predicted)
• PKA: 0.12±0.25(Predicted)
• PSA: 70.16000
• Density: 1.324±0.06 g/cm3(Predicted)
• LogP: 0.68990
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-hydroxy-2,6-dimethylnicotinicacid 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Hydroxy-2,6-diMethylnicotinic acid

There total 9 articles about 4-Hydroxy-2,6-diMethylnicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

ethyl 4-hydroxy-2,6-dimethylpyridin-3-carboxylate (33831-56-0) → 2,6-dimethyl-4-hydroxypyridine-3-carboxylic acid (33259-21-1)

Guidance literature:

With sodium hydroxide; for 4h; Reflux;

DOI:10.1016/j.ica.2011.04.009

Reference yield: 82.0%

2,6-dimethyl-4-oxopyran-3-carboxylic acid (3265-58-5) → 2,6-dimethyl-4-hydroxypyridine-3-carboxylic acid (33259-21-1)

Guidance literature:

With ammonium hydroxide; for 18h; Ambient temperature;

Reference yield: 65.0%

2,6-dimethylpyridine-3-carboxylic acid (5860-71-9) → 2,6-dimethyl-4-hydroxypyridine-3-carboxylic acid (33259-21-1)

Guidance literature:

With oxygen; potassium acetate; palladium diacetate; C₁₉H₂₄N₂O; p-benzoquinone; In N,N-dimethyl-formamide; at 110 ℃; for 24h; under 760.051 Torr; regioselective reaction;

DOI:10.1126/science.abg2362

upstream raw materials:

ethyl 4-hydroxy-2,6-dimethylpyridin-3-carboxylate

ethyl 4-chloro-2,6-dimethylnicotinate

ethyl aminocrotonate

2,6-dimethyl-4-oxopyran-3-carboxylic acid