ethyl 4-chloro-2,6-dimethyl-pyridine-3-carboxylate

Base Information

• Chemical Name: ethyl 4-chloro-2,6-dimethyl-pyridine-3-carboxylate
• CAS No.: 70271-80-6
• Molecular Formula: C10H12 Cl N O2
• Molecular Weight: 213.664
• Hs Code.: 2933399090
• Mol file: 70271-80-6.mol

Synonyms:Ethyl4-chloro-2,6-dimethylnicotinate; Ethyl4-chloro-2,6-dimethylpyridine-3-carboxylate; NSC 44686

Chemical Property of ethyl 4-chloro-2,6-dimethyl-pyridine-3-carboxylate

Chemical Property:

• Vapor Pressure: 0.00907mmHg at 25°C
• Boiling Point: 265.6°Cat760mmHg
• PKA: 3.86±0.10(Predicted)
• Flash Point: 114.4°C
• PSA: 39.19000
• Density: 1.176g/cm³
• LogP: 2.52850
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl4-chloro-2,6-dimethylnicotinate 97% ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 4-chloro-2,6-dimethyl-pyridine-3-carboxylate

There total 7 articles about ethyl 4-chloro-2,6-dimethyl-pyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

ethyl 3-aminobut-2-enoate (626-34-6) → ethyl 4-chloro-2,6-dimethylnicotinate (70271-80-6)

Guidance literature:

With trichlorophosphate; at 90 ℃;

DOI:10.1016/S0040-4020(01)91918-0

Reference yield:

ethyl aminocrotonate (626-34-6,7318-00-5,41867-20-3) → ethyl 4-chloro-2,6-dimethylnicotinate (70271-80-6)

Guidance literature:

With trichlorophosphate; benzene;

Reference yield:

→ ethyl 4-chloro-2,6-dimethylnicotinate (70271-80-6)

Guidance literature:

With phosphorus pentachloride; at 160 ℃;

upstream raw materials:

ethyl aminocrotonate

ethyl 3-aminobut-2-enoate

ethyl 4-hydroxy-2,6-dimethylpyridin-3-carboxylate

phosphorus pentachloride

Downstream raw materials:

ethyl 2,6-dimethyl-4-[2-(2,4-dimethylphenoxy)ethylamino]nicotinate

ethyl 2,6-dimethyl-4-(4-phenylcyclohexylamino)nicotinate

Ethyl 2,6-dimethyl-4-[N-(4-butylphenyl)piperidin⁽⁴⁾-ylamino]-nicotinate

ethyl 2,6-dimethyl-4-[2-methyl-3-(4-tert-butylcyclohexyl)propylamino]nicotinate

Refernces

• 1、 Newkome, George R.,Marston, Charles R.. "NICOTINIC ACID CROWN ETHERS: SYNTHESIS, COMPLEXATION AND REDUCTION". . p. 2001 - 2008. Retrieved 2007/10/02.