1-Piperidinecarboxylic acid, 4-(4-chlorophenoxy)-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: 1-Piperidinecarboxylic acid, 4-(4-chlorophenoxy)-, 1,1-dimethylethyl ester
• CAS No.: 333954-83-9
• Molecular Formula: C16H22ClNO3
• Molecular Weight: 311.809

Synonyms:4-(4-chloro-phenoxy)-piperidin-1-carboxylic acid tert-butyl ester;tert-butyl 4-(4-chlorophenoxy)-1-piperidinecarboxylate;4-(4-chlorophenoxy)-piperidine-1-carboxylic acid tert-butyl ester;4-(4-chlorophenoxy)piperidine-1-carboxylic acid tert-butyl ester;4-(4-chloro-phenoxy)-piperidinecarboxylic acid t-butyl ester;

Chemical Property of 1-Piperidinecarboxylic acid, 4-(4-chlorophenoxy)-, 1,1-dimethylethyl ester

Chemical Property:

• PSA: 38.77000
• LogP: 4.05620

Purity/Quality:

99% ^*data from raw suppliers

tert-Butyl4-(4-chlorophenoxy)-piperidine-1-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Piperidinecarboxylic acid, 4-(4-chlorophenoxy)-, 1,1-dimethylethyl ester

There total 5 articles about 1-Piperidinecarboxylic acid, 4-(4-chlorophenoxy)-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.5%

1-Chloro-4-fluorobenzene (352-33-0) → tert-butyl 4-(4-chlorophenoxy)piperidine-1-carboxylate (333954-83-9)

Guidance literature:

t-butyl 4-hydroxy piperidine-1-carboxylate; With sodium hydride; In N,N-dimethyl-formamide; at 40 ℃; for 1h;

1-Chloro-4-fluorobenzene; In N,N-dimethyl-formamide; at 20 - 80 ℃; for 4h;

Reference yield: 58.0%

4-chloro-phenol (106-48-9,82344-39-6) + t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) → tert-butyl 4-(4-chlorophenoxy)piperidine-1-carboxylate (333954-83-9)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield:

4-chloro-phenol (106-48-9,82344-39-6) + t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) → tert-butyl 4-(4-chlorophenoxy)piperidine-1-carboxylate (333954-83-9) + (2E)-3-(4-Chlorophenyl)-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(2-pyridyloxy)-1-piperidinyl]ethyl}amino)-1-(2-pyridylmethyl)ethyl]-acrylamide (442198-38-1)

Guidance literature:

upstream raw materials:

4-chloro-phenol

t-butyl 4-hydroxy piperidine-1-carboxylate

1-Chloro-4-fluorobenzene

Downstream raw materials:

4-(4-chlorophenoxy)piperidine hydrochloride

4-(4-chlorophenoxy)-piperidine

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-({2-[4-(4-chlorophenoxy)-1-piperidinyl]-2-oxoethyl}amino)-2-oxo-1-(2-pyridylmethyl)ethyl]-2-propenamide

5-Chloro-N-[(1S)-2-({2-[4-(4-chlorophenoxy)-1-piperidinyl]-2-oxoethyl}amino)-2-oxo-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide

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