4-fluoro-N-(4-methoxyphenyl)benzamide

Base Information

• Chemical Name: 4-fluoro-N-(4-methoxyphenyl)benzamide
• CAS No.: 33489-70-2
• Molecular Formula: C14H12FNO2
• Molecular Weight: 245.253
• DSSTox Substance ID: DTXSID70336287
• Nikkaji Number: J879.364F
• Wikidata: Q82103277
• Mol file: 33489-70-2.mol

Synonyms:4-fluoro-N-(4-methoxyphenyl)benzamide;33489-70-2;4-Fluoro-N-(4-methoxy-phenyl)-benzamide;Benzamide, N-(4-methoxyphenyl)-4-fluoro-;Oprea1_428271;Oprea1_821987;SCHEMBL6295993;JUEQLTHFAHLSAQ-UHFFFAOYSA-;DTXSID70336287;MFCD00439109;STK041258;AKOS000491101;N-(4-Methoxyphenyl)-4-fluorobenzamide;CS-0327749;EU-0037036;SR-01000421891;SR-01000421891-1;Z28138923

Chemical Property of 4-fluoro-N-(4-methoxyphenyl)benzamide

Chemical Property:

• PSA: 41.82000
• LogP: 3.47060
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 245.08520679
• Heavy Atom Count: 18
• Complexity: 269

Purity/Quality:

99% ^*data from raw suppliers

4-Fluoro-N-(4-methoxy-phenyl)-benzamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)NC(=O)C2=CC=C(C=C2)F

Technology Process of 4-fluoro-N-(4-methoxyphenyl)benzamide

There total 8 articles about 4-fluoro-N-(4-methoxyphenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-fluorobenzoyl chloride (403-43-0) + 4-methoxy-aniline (104-94-9) → 4-fluoro-N-(4-methoxyphenyl)benzamide (33489-70-2)

Guidance literature:

In N,N-dimethyl-formamide; 1.) 48 h; 2.) 0 deg C, 15 min;

Reference yield: 89.0%

phenyl 4-fluorobenzoate (2714-90-1) + 4-methoxy-aniline (104-94-9) → 4-fluoro-N-(4-methoxyphenyl)benzamide (33489-70-2)

Guidance literature:

With C₄₀H₅₄ClN₂Pd; caesium carbonate; In tetrahydrofuran; water; at 60 ℃; for 4h; Glovebox; Inert atmosphere;

DOI:10.1021/acs.joc.7b02588

Reference yield: 71.0%

4-fluoro-N-phenylbenzamide (366-63-2) + 4-methoxy-aniline (104-94-9) → 4-fluoro-N-(4-methoxyphenyl)benzamide (33489-70-2)

Guidance literature:

With manganese; chloro-trimethyl-silane; briphos; In 1-methyl-pyrrolidin-2-one; at 160 ℃; for 16h;

DOI:10.1021/acs.orglett.8b03304

upstream raw materials:

4-fluorobenzoyl chloride

4-methoxy-aniline

para-iodoanisole

para-fluorobenzylamine

Downstream raw materials:

N-(p-anisyl)-4-fluorobenzenecarboxyimidoyl chloride

2-(4-fluorophenyl)-6-methoxy-1,3-benzoxazole

C₁₅H₁₄FNO₃S

6-fluoro-2-(4-methoxyphenyl)benzo[d]isothiazol-3(2H)-one