N-(3-Methoxy-4-benzyloxy-phenaethyl)-2-benzyloxy-phenacetamid

Base Information

• Chemical Name: N-(3-Methoxy-4-benzyloxy-phenaethyl)-2-benzyloxy-phenacetamid
• CAS No.: 22136-46-5
• Molecular Formula: C₃₁H₃₁NO₄
• Molecular Weight: 481.591
• Mol file: 22136-46-5.mol

Synonyms:

Chemical Property of N-(3-Methoxy-4-benzyloxy-phenaethyl)-2-benzyloxy-phenacetamid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3-Methoxy-4-benzyloxy-phenaethyl)-2-benzyloxy-phenacetamid

There total 3 articles about N-(3-Methoxy-4-benzyloxy-phenaethyl)-2-benzyloxy-phenacetamid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2-benzyloxyphenyl)acetonitrile (92552-22-2) → N-(3-Methoxy-4-benzyloxy-phenaethyl)-2-benzyloxy-phenacetamid (22136-46-5)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. KOH

2: 180 - 190 °C

With potassium hydroxide;

DOI:10.1039/j39690000502

Reference yield:

2-(phenylmethoxy)benzaldehyde (5896-17-3) → N-(3-Methoxy-4-benzyloxy-phenaethyl)-2-benzyloxy-phenacetamid (22136-46-5)

Guidance literature:

Multi-step reaction with 3 steps

1: (i) NaBH₄, (ii) SOCl₂, (iii) /BRN= 3587243/, NaI

2: aq. KOH

3: 180 - 190 °C

With potassium hydroxide;

DOI:10.1039/j39690000502

Reference yield:

2-[4-(benzyloxy)-3-methoxyphenyl]ethylamine (22231-61-4) + 2-hydroxyphenylacetic acid benzyl ether (22047-88-7) → N-(3-Methoxy-4-benzyloxy-phenaethyl)-2-benzyloxy-phenacetamid (22136-46-5)

Guidance literature:

at 180 - 190 ℃;

DOI:10.1039/j39690000502

upstream raw materials:

2-[4-(benzyloxy)-3-methoxyphenyl]ethylamine

2-hydroxyphenylacetic acid benzyl ether

(2-benzyloxyphenyl)acetonitrile

2-(phenylmethoxy)benzaldehyde