92552-22-2

Usage

Uses

Used in Pharmaceutical Industry:
2-BENZYLOXYPHENYLACETONITRILE is used as a key intermediate for the synthesis of nonsteroidal anti-inflammatory drugs (NSAIDs), which are essential in managing inflammation and pain. Its role in the production of these drugs is vital due to its ability to contribute to the formation of the active pharmaceutical ingredients.
Used in Organic Chemistry:
2-BENZYLOXYPHENYLACETONITRILE is utilized as a building block in the synthesis of other organic compounds. Its structural properties allow it to be a versatile component in creating a wide range of chemical products, enhancing its utility across various applications in organic chemistry.

InChI:InChI=1/C9H9NO/c10-6-7-11-8-9-4-2-1-3-5-9/h1-5H,7-8H2

Upstream product

• 143-33-9 sodium cyanide 
• 5896-17-3 2-(phenylmethoxy)benzaldehyde 
• 23915-08-4 2-benzyloxybenzyl chloride 
• 90-01-7 salicylic alcohol 
• 89-95-2 2-methyl-benzyl alcohol 
• 100-39-0 benzyl bromide 
• 74511-44-7 o-(benzyloxy)benzonitrile 
• 14389-86-7 2-benzyloxybenzoic acid 
• 773837-37-9 sodium cyanide 
• 611-20-1 salicylonitrile 
• 3381-87-1 2-benzyloxybenzyl alcohol 
• 13435-20-6 tetraethylammoniumcyanide 
• 92963-94-5 2-Benzyloxy-phenylbrenztraubensaeure-oxim 

Downstream Products

• 860114-04-1 4-(2-benzyloxy-phenyl)-1-methyl-piperidine-4-carbonitrile 
• 65576-45-6 asenapine 
• 22136-46-5 N-(3-Methoxy-4-benzyloxy-phenaethyl)-2-benzyloxy-phenacetamid 
• 251359-94-1 4-(4-Chlorophenyl)-4-hydroxy-α-[2-(phenylmethoxy)-phenyl]-1-piperidinepentanenitrile 
• 40525-65-3 2-benzyloxyphenylacetic acid methyl ester 
• 881672-60-2 2,2-dimethyl-propionic acid 2-(2-benzyloxy-phenyl)-3-hydroxy-propyl ester 
• 881672-71-5 dimethyl 2-[2-(benzyloxy)benzyl]malonate 

Relevant academic research and scientific papers

High diastereoselectivity in the yang photocyclization via remote hydrogen abstraction reaction

1-Benzoyl-1-(o-alkoxyphenyl)cyclopropanes undergo Yang photocyclization to form dihydrobenzopyranols in a stereospecific manner. The cyclopropyl group at alpha position to carbonyls gives not only a bias in the most stable geometries of the starting ketones but also conformational restriction on geometries of biradical intermediates. More importantly, intramolecular hydrogen bonds seem to give an additional effect on conformational control of the biradical reactivity.

2-Benzyl and 2-phenyl-3-hydroxypropyl pivalates as protein kinase C ligands

A series of 2-benzyl and 2-phenyl-3-hydroxypropyl pivalates designed to incorporate the principal pharmacophores of phorbol esters have been synthesized and tested as PKC-α ligands. Among the analogues, 13c exhibited the most potent binding affinity with a Ki = 0.7 μM. The synthesized analogues were subjected to molecular modeling analysis based on two alternative models of the phorbol pharmacophore and a docking study of 13c was carried out.

Design, synthesis and antiproliferative activity of tripentones: A new series of antitubulin agents

Structure-activity relationship studies of a new series of tripentones (thieno[2,3-b]pyrrolizin-8-ones), led us to prepare several derivatives with antiproliferative activities. The most promising 3-(3-hydroxy-4-methoxyphenyl)thieno[2,3-b]pyrrolizin-8-one 20 (leukemia L1210, IC50 = 15 nM) was shown to be a potent inhibitor of tubulin polymerization.

Compounds and pharmaceutical use thereof

PCT No. PCT/JP97/00291 Sec. 371 Date Aug. 6, 1998 Sec. 102(e) Date Aug. 6, 1998 PCT Filed Feb. 6, 1997 PCT Pub. No. WO97/29079 PCT Pub. Date Aug. 14, 1997The compounds of the formula (I) wherein each symbol is as defined in the specification, pharmaceutically acceptable salts thereof and pharmaceutical use thereof. The Compound (I) and pharmaceutically acceptable salts thereof of the present invention selectively act on cannabinoid receptors, particularly peripheral receptors, cause less side effects on the central system, and have superior immunoregulating action, antiinflammatory action, antiallergic action and therapeutic effect on nephritis. Therefore, they are useful as cannabinoid receptor, particularly peripheral cannabinoid receptor activators and antagonists, immunoregulators, therapeutic agents for autoimmune diseases, antiinflammatory agents, antiallergic agents and therapeutic agents for nephritis.