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2-BENZYLOXYPHENYLACETIC ACID is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

22047-88-7

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22047-88-7 Usage

Synthesis Reference(s)

Journal of the American Chemical Society, 64, p. 3051, 1942 DOI: 10.1021/ja01264a515

Check Digit Verification of cas no

The CAS Registry Mumber 22047-88-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,2,0,4 and 7 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 22047-88:
(7*2)+(6*2)+(5*0)+(4*4)+(3*7)+(2*8)+(1*8)=87
87 % 10 = 7
So 22047-88-7 is a valid CAS Registry Number.
InChI:InChI=1/C15H14O3/c16-15(17)10-12-6-4-5-7-13(12)11-18-14-8-2-1-3-9-14/h1-9H,10-11H2,(H,16,17)

22047-88-7 Well-known Company Product Price

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  • Alfa Aesar

  • (A15237)  2-Benzyloxyphenylacetic acid, 98+%   

  • 22047-88-7

  • 1g

  • 831.0CNY

  • Detail
  • Alfa Aesar

  • (A15237)  2-Benzyloxyphenylacetic acid, 98+%   

  • 22047-88-7

  • 5g

  • 3211.0CNY

  • Detail
  • Alfa Aesar

  • (A15237)  2-Benzyloxyphenylacetic acid, 98+%   

  • 22047-88-7

  • 25g

  • 13382.0CNY

  • Detail

22047-88-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(2-phenylmethoxyphenyl)acetic acid

1.2 Other means of identification

Product number -
Other names O-Benzyloxyphenylacetic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:22047-88-7 SDS

22047-88-7Relevant academic research and scientific papers

PYRIDINE COMPOUND SUBSTITUTED WITH AZOLE

-

Paragraph 0940, (2020/07/07)

The present invention provides a compound represented by formula [I] shown below or a pharmaceutically acceptable salt thereof that has an inhibitory effect on 20-HETE producing enzyme. (in formula [I] above, the structure represented by formula [II] below: represents any of the structures represented by formula group [III] below: R1, R2, R3, and R4 independently represent a hydrogen atom, a fluorine atom, methyl, or the like, R5 represents any of the structures represented by formula group [IV]:

Metal-Free Tandem Rearrangement/Lactonization: Access to 3,3-Disubstituted Benzofuran-2-(3H)-ones

Santi, Micol,Ould, Darren M. C.,Wenz, Jan,Soltani, Yashar,Melen, Rebecca L.,Wirth, Thomas

supporting information, p. 7861 - 7865 (2019/04/25)

A novel metal-free synthesis of 3,3-disubstituted benzofuran-2-(3H)-ones through reacting α-aryl-α-diazoacetates with triarylboranes is presented. Initially, triarylboranes were successfully investigated in α-arylations of α-diazoacetates, however in the presence of a heteroatom in the ortho position, the boron enolate intermediate undergoes an intramolecular rearrangement to form a quaternary center. The intermediate cyclizes to afford valuable 3,3-disubstituted benzofuranones in good yields.

(2-Benzyloxyphenyl)acetyl (BnPAc): A Participating Relay Protecting Group for Diastereoselective Glycosylation and the Synthesis of 1,2-trans Glycosyl Esters

Weber, Julia,Krauter, Simon,Schwarz, Theresa,Hametner, Christian,Mikula, Hannes

supporting information, p. 2265 - 2268 (2018/10/20)

The (2-benzyloxyphenyl)acetyl group has been identified as a new protecting group for hydroxyl functions. Various alcohols could be easily protected with high yields, and deprotection was achieved by a relay approach using Pd/H 2 in combination with 1,8-bis(dimethylamino)naphthalene, conditions that are orthogonal to ester groups. The new protecting group is stable in glycosylation reactions demonstrating an effective neighboring group participation leading to the exclusive formation of 1,2-trans glycosides and glycosyl esters.

Total synthesis and stereochemical revision of xiamenmycin A

Jiao, Xiaozhen,Yao, Yangyang,Yang, Beibei,Liu, Xiaoyu,Li, Xiaoyu,Yang, Hongguang,Li, Li,Xu, Jun,Xu, Minjuan,Xie, Ping

, p. 1805 - 1813 (2016/02/10)

The relative and absolute configurations of xiamenmycin A, a benzopyran compound isolated from Streptomyces xiamenensis 318 with a highly potent anti-fibrotic activity, have been characterized through the total synthesis. The key steps include the constru

Synthesis and in vitro antitumor activity of asperphenamate derivatives as autophagy inducer

Yuan, Lei,Li, Yanchun,Zou, Chunyang,Wang, Chao,Gao, Jian,Miao, Caixia,Ma, Enlong,Sun, Tiemin

scheme or table, p. 2216 - 2220 (2012/04/18)

In an effort to improve the aqueous solubility and the antitumor activity of natural product asperphenamate, we have designed and synthesized three series of asperphenamate derivatives, including series I (simplifying molecular skeleton series), series II (introducing a hydroxyl group to A-phenyl ring series) and series III (disrupting molecular planarity series). All derivatives have displayed a significantly increased solubility compared with asperphenamate. Their growth inhibitory activities in vitro were screened by the standard MTT method in MCF-7, HeLa, and BEL-7402 cell lines. With the exception of the derivatives in series I, most of derivatives in series II and series III showed growth inhibitory activity. Among all derivatives, IM23b in series III showed the greatest potency in human breast cancer MCF-7 cells. The cellular potency of IM23b was approximately 1.5-fold more potent than that of cisplatin. The mechanism of cell death induced by IM23b in human breast cancer MCF-7 cells was further investigated. We concluded that the cell death was induced by autophagy instead of apoptosis or cell cycle arrest.

2-Benzyl and 2-phenyl-3-hydroxypropyl pivalates as protein kinase C ligands

Lee, Jeewoo,Lee, Ju-Hyun,Kim, Su Yeon,Perry, Nicholas A.,Lewin, Nancy E.,Ayres, Jolene A.,Blumberg, Peter M.

, p. 2022 - 2031 (2007/10/03)

A series of 2-benzyl and 2-phenyl-3-hydroxypropyl pivalates designed to incorporate the principal pharmacophores of phorbol esters have been synthesized and tested as PKC-α ligands. Among the analogues, 13c exhibited the most potent binding affinity with a Ki = 0.7 μM. The synthesized analogues were subjected to molecular modeling analysis based on two alternative models of the phorbol pharmacophore and a docking study of 13c was carried out.

Substituted compounds derived from N-(benzyl)phenylacetamide, preparation and uses

-

Page/Page column 50, (2010/10/20)

This invention relates to poly-substituted derivatives of the N-(benzyl)phenylacetamide type, pharmaceutical compositions comprising same, therapeutic uses thereof, more particularly in the fields of human and animal health. This invention also relates to a process for the preparation of such derivatives.

Endothelin antagonists

-

, (2008/06/13)

A compound of formula (I), in which: R1is lower alkyl, cyclo(lower)alkyl, optionally substituted aryl, optionally substituted heterocyclic group, cyclo(lower)alkyl(lower)alkyl, or ar(lower)alkyl; R2is hydrogen, hydroxy or protected h

Efficient synthesis of 1-Benzyloxyphenyl-3-phenylacetones

Mannekens,Tourwe,Lubell

, p. 1214 - 1216 (2007/10/03)

1-[(Benzyloxy)phenyl]-3-phenylacetones 1a-c have been conveniently synthesized by acylation of the PhCH2Li-DABCO complex with their respective N-methyl O-methyl hydroxamates 5a-c. In four steps, ketones 1a-c having ortho-, meta- and para-benzyloxy substituents were obtained in 42-51% overall yields from commercially available 2-(hydroxyphenyl)acetic acids.

Polymer-Supported Mitsunobu Ether Formation and its Use in Combinatorial Chemistry

Krchnak, Viktor,Flegelova, Zuzka,Weichsel, Aleksandra S.,Lebl, Michal

, p. 6193 - 6196 (2007/10/02)

Aromatic hydroxy acids have been attached to a polymeric solid support and the phenolic hydroxy groups have been reacted with a variety of primary and secondary alcohols under the conditions of the Mitsunobu reaction (triphenylphosphine and diethyl azodicarboxylate) in tetrahydrofuran.In most cases the reaction provided a nearly quantitative yield of alkyl aryl ethers, as determined after cleaving theproduct from the resin.To demonstrate that the polymer-supported Mitsunobu reaction is useful for combinatorial library synthesis, we synthesized a number of model compounds and a simple three randomization step library composed of 4,200 different compounds.

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