Spiro[3H-indole-3,3'-[3H]pyrazole]-4',5'-dicarboxylic acid, 2'-(4-chlorophenyl)-1,2,2',4'-tetrahydro-1-methyl-2-oxo-, dimethyl ester, trans-

Base Information

Chemical Name:Spiro[3H-indole-3,3'-[3H]pyrazole]-4',5'-dicarboxylic acid, 2'-(4-chlorophenyl)-1,2,2',4'-tetrahydro-1-methyl-2-oxo-, dimethyl ester, trans-
CAS No.:113258-75-6
Molecular Formula:C₂₁H₁₈ClN₃O₅
Molecular Weight:427.844
Hs Code.:
Mol file:113258-75-6.mol

Synonyms:

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Chemical Property of Spiro[3H-indole-3,3'-[3H]pyrazole]-4',5'-dicarboxylic acid, 2'-(4-chlorophenyl)-1,2,2',4'-tetrahydro-1-methyl-2-oxo-, dimethyl ester, trans-

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Technology Process of Spiro[3H-indole-3,3'-[3H]pyrazole]-4',5'-dicarboxylic acid, 2'-(4-chlorophenyl)-1,2,2',4'-tetrahydro-1-methyl-2-oxo-, dimethyl ester, trans-

There total 4 articles about Spiro[3H-indole-3,3'-[3H]pyrazole]-4',5'-dicarboxylic acid, 2'-(4-chlorophenyl)-1,2,2',4'-tetrahydro-1-methyl-2-oxo-, dimethyl ester, trans- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 113258-76-7,61936-93-4
(E)-(2-oxo-1,2-dihydro-1-methylindol-3-ylidene)acetic acid methyl ester

: 62465-90-1
methyl (N-(4-chlorophenyl)hydrazono)chloroacetate

: 113258-75-6
1-methyl-2-indolinone-3-spiro-5'-1'-p-chlorophenyl-3',4'-dimethoxycarbonyl-2'-pyrazoline

Guidance literature:: With triethylamine; In benzene;
DOI:10.1016/S0040-4020(01)86889-7

Reference yield: 11.0%

: 110784-09-3
dimethyl 2-1'-methyl-2'-oxindolin-3'-yliden-3-oxo-succinate

: 1073-69-4
N-4-chlorophenylhydrazine

: 113258-69-8
1-methylisatin-3-p-chlorophenylhydrazone

: 113258-75-6
1-methyl-2-indolinone-3-spiro-5'-1'-p-chlorophenyl-3',4'-dimethoxycarbonyl-2'-pyrazoline

Guidance literature:: In 1,4-dioxane; Heating;
DOI:10.1016/S0040-4020(01)86889-7

Reference yield:

: 106-47-8
4-chloro-aniline

: 113258-75-6
1-methyl-2-indolinone-3-spiro-5'-1'-p-chlorophenyl-3',4'-dimethoxycarbonyl-2'-pyrazoline

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaNO₂, H⁽¹⁺⁾; 2.) sodium acetate / 1.) H₂O, 0 to 50 deg C; 2.) H₂O

2: 44 percent / Et₃N / benzene

With sodium acetate; hydrogen cation; triethylamine; sodium nitrite; In benzene;
DOI:10.1016/S0040-4020(01)86889-7